Both primary tumor growth and spontaneous metastases were increased in NSG mice compared to nude mice. In addition, a pattern of metastasis similar to that observed in human breast cancer patients (metastases to the lungs, liver, bones, brain, and lymph nodes) was found ...
Here, by flow cytometry, we evaluated the reconstitution of CXCR5+ CD8+ T-cells in huNSG mice engrafted with CD34+ hematopoietic stem cells. This population was readily generated in huNSG mice, and where particularly confined to spleen and lymph nodes. These cells exhibited a follicular-like ...
It has also been shown to be expressed in the trachea [64] and in lymphoid organs such as tonsils and lymph nodes [65]. Normal epithelial and fetal tissues have low expression of CD147, when measured by immunohistochemical analysis [66]. However, CD147 is significantly upregulated in ...
of human T cells in the peripheral blood of 3-month-old mice was higher in NSG wt mice, and the proportion of circulating B cells at the same time was higher in NSG-cmah−/−mice. By 6 months of age, there were similar proportions of T and B cells in the peripheral blood (...
Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes. PLoS Pathog. 2018, 14, e1006902. [CrossRef] 105. McBrien, J.B.; Mavigner, M.; Franchitti, L.; Smith, S.A.; White, E.; Tharp, G.K.; Walum, H.; Busman-Sahay, K.; ...
IL-15-treatments also increased activated cytotoxic T lymphocytes (CTLs) and NK cells, reducing SHIV in the lymph nodes of non-human primates (NHP) [104]. More recently, therapeutic levels of N-803 strongly and persistently reactivated SIV in CTL-depleted NHP [105]. Therefore, we ...
In this model, HCMV reactivation by treatment with recombinant human G-CSF promoted the detection of the virus in the spleen, lymph nodes, liver, salivary glands and bone marrow. Interestingly, HCMV infection enhanced T cell development in the thymus of these mice, which was associated with ...