发现NSG-SGM3小鼠从第4周开始,髓系、B-淋巴细胞、T-淋巴细胞重建逐渐高于NSG小鼠;T-淋巴细胞升高主要是人CD4细胞升高。NSG-SGM3抗体水平表达水平升高,可以产生特异性抗病毒抗体。 参考文献 JangalweS, Shultz LD, Mathew A, Brehm MA. Improved B cell development in humaniz...
NSG-SGM3小鼠AML的移植效率提高;人造血干细胞移植后髓系发育水平提高。 实验显示,NSG和NSG-SGM3两种小鼠出生后3~4周照射后移植同一供体人CD34+细胞,不同时间观察外周血人源免疫细胞比例。发现NSG-SGM3小鼠从第4周开始,髓系、B-淋巴细胞、T-淋巴细胞重建逐渐高于NSG小鼠;T-淋巴细胞升高主要是人CD4细胞升高。NSG-...
NSG-SGM3小鼠血清中组成型产生2~4ng/ml的人IL-3, GM-CSF及SF。移植骨髓和肝细胞后,Il2rg-/-特异性NOD.SCID小鼠支持人和小鼠的造血细胞植入,髓系生成水平升高;人红系生成及B-淋巴细胞生成较低。NSG-SGM3小鼠AML的移植效率提高;人造血干细胞移植后髓系发育水平提高。 实验显示,NSG和NSG-SGM3两种小鼠出生后3...
英文名称: NSG-SGM3 总访问: 5065 国产/进口: 进口 半年访问: 482 产地/品牌: 杰克森实验室(JAX) 产品类别: 实验动物 规格: NSG-SGM3 最后更新: 2024-11-20 货号: 013062 参考报价: 询价议价 立即询价 电话咨询 [发表评论] [本类其他产品] [本类其他供应商] [收藏] 分享:微信新浪微博销售商: ...
在表达SCF、GM-CSF(也称为CSF2)和IL-3(NSG-SGM3)的NSG(Prkdc和IL2rg基因敲除)小鼠中,移植了卵巢癌PDX和自体PBMC的肿瘤生长受到抑制,这些小鼠暴露于抗PD-1和抗CTLA4抗体,但不单独暴露抗PD-1抗体,与未暴露、未植入NSG-SG3M PDX MICE相比。与未暴露的小鼠相比,移植了胃癌PDX和自体PBMC的BRG小鼠(Rag2和IL2rg...
Thus, PDX-bearing hu-NSG-SGM3 mice might serve as a new and improved platform for preclinical immuno-oncology efficacy studies.Citation Format: Li-Chin Yao, Mingshan Cheng, Minan Wang, Jacques Banchereau, Karolina Palucka, Leonard Shultz, Carol Bult, James G. Keck. Patient-derived tumor ...
The second feature is the predisposition of NSG-SGM3 mice given these human cells to develop eosinophil hyperplasia. The third feature, secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS)–like disease, is the most pronounced in both its clinical and histopathologic ...
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METHODS :We grafted human CD34 + hematopoietic stem cells into NSG-SGM3 (NSGS) mice. The hu-NSGS mice underwent total body irradiation at doses of 2, 3, and 4Gy. Tissues from the spleen, thymus, and lymph nodes of hu-NSGS mice were prepared to analyze levels of CD45 + and CD3 ...
NSG‐SGM3PD‐1T cellThe humanized NOD/SCID/IL‐2 receptor γ‐chainnull (NSG) mouse model has been widely used for the study of HIV pathogenesis. Here, NSG mice with transgenic expression of human stem cell factor (SCF), granulocyte–macrophage colony‐stimulating factor (GM‐CSF) and ...