Next, to launch a CRS mouse model, FT-CAR T cells were administered into NSG-SGM3 mice engrafted with Nalm-6 cells. Mice received 1x107 FT-CAR or activated T cells intravenously. Health condition assessment and body index calculation were regularly monitored using weight, and body temperature...
A number of mouse models genetically engineered to harbor mutations common to CMML and JMML have provided important mechanistic insights into disease pathogenesis.2,3 However, these models lack the tumor heterogeneity inherent to human hematological malignancies. The capacity of xenograft models to recapit...
In addition, HIV replication and the activation/differentiation disturbances of T cells were associated with decreased plasma levels of IL‐17A. Thus, this hu‐PBL‐NSG‐SGM3 mouse model recapitulates some immune disturbances occurring in HIV‐infected patients, underlying its potential use for ...
The present study attempted to identify candidate microRNA (miRNA) biomarkers for radiation exposure in a hematopoietic humanized NSGS (hu-NSGS) mouse model. METHODS :We grafted human CD34 + hematopoietic stem cells into NSG-SGM3 (NSGS) mice. The hu-NSGS mice underwent total body irradiation...