Development and function of human innate immune cells in a humanized mouse model. Mice repopulated with human hematopoietic cells are a powerful tool for the study of human hematopoiesis and immune function in vivo. However, existing hum... A Rongvaux,T Willinger,J Martinek,... - 《Nature ...
A number of mouse models genetically engineered to harbor mutations common to CMML and JMML have provided important mechanistic insights into disease pathogenesis.2,3 However, these models lack the tumor heterogeneity inherent to human hematological malignancies. The capacity of xenograft models to recapit...
The present study attempted to identify candidate microRNA (miRNA) biomarkers for radiation exposure in a hematopoietic humanized NSGS (hu-NSGS) mouse model. METHODS :We grafted human CD34 + hematopoietic stem cells into NSG-SGM3 (NSGS) mice. The hu-NSGS mice underwent total body irradiation...