在这项研究中,研究人员发现阿司匹林抑制结直肠癌的一种信号传导通路,阿司匹林(乙酰水杨酸)可以激活AMPK和抑制c-MYC来激活NRF2/ARE/miR-34a/b/c级联,从而抑制结直肠癌的转移。具体来说,水杨酸可以促进AMPK的磷酸化,进而抑制c-MYC的表达。而c-MYC的高表达与多种肿瘤的发生和发展密切相关。此外,水杨酸还可以通过激活NR...
另外,紫檀芪(20μmol/L)显著上调氧化应激MC3T3-E1中c-myc和Nrf2的蛋白表达量(**P<0.01).干扰c-myc表达可有效抑制紫檀芪对氧化应激MC3T3-E1的Nrf2蛋白表达量(**P<0.01),细胞活力(**P<0.01),LDH漏出量(**P<0.01),caspase-3活性(**P<0.01)和ROS水平(**P<0.01)的作用.结论 紫檀芪可通过c-myc调控Nrf2表达...
实验进一步验证了NRF2激活与HDAC抑制剂敏感性之间的关联在人体细胞中的一致性。结果显示，NRF2激活的A549细胞对罗米地辛表现出更敏感性，且在KEAP1WT或突变型肿瘤的PDX中，romidepsin处理可更早更强地抑制NRF2活性肿瘤的生长，降低了c-MYC水平。A549异种移植肿瘤对罗米地辛和CB-839的联合作用非常敏感，这...
c-Myc showed the same age and induction profile while the age increase in Bach1 was further induced by nPM. Chronic exposure to nanoparticles induced Nrf2-regulated detoxifying enzymes in brain (cerebellum), liver, and lung of young adult mice, indicating a systemic impact of nPM. In contrast...
这些数据表明,HNF4α促进Nrf2激活,而cMyc抑制Nrf2功能。在HNF4α-KO条件下,cMyc被诱导,进而抑制Nrf2,导致更高程度的肝损伤。而在HNF4α-KO中抑制cMyc,即在DKO小鼠中,Nrf2激活恢复,导致GSH快速补充,肝损伤减轻。 图7 APAP造模后D...
(NRF2). Furthermore, we demonstrated that the suppression of c-MYC by salicylate is required for NRF2-mediated activation ofmiR-34aexpression. The induction ofmiR-34awas necessary for multiple tumor suppressive effects of salicylate, including the repression of cell viability, migration, invasion, ...
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(F) Immunohistochemistry (IHC) staining of c-MYC and quantitation in KP NRF2 tumors after 17 days of treatment with DMSO or romidepsin (n = 4 tumor sections, Fisher’s least significant difference [LSD] statistical test; related to Figures 2I and 2J). (G) Rank plot of gene promoter H...
Representative blot pictures and densitometric evaluations (relative myc (β-TrCP)/GFP (Nrf2) signal) are depicted. (n = 6, mean +SD; *P < 0.05, Welch's t-test, two tailed, α = 0.05). In conclusion, activation of AMPK can prolong abundance of Nrf2. The identified phosphosites at S...
前列腺癌组织中Nrf2,c-Myc 蛋白 表达变化及意doi:10.3969/j.issn.1002-266X.2018.05.024郝斌苗志刚袁媛季德才Shandong Medical Journal