IF 12.9)发表了题为“Co-mutation landscape and its prognostic impact on newly diagnosed adult patients with NPM1-mutated de novo acute myeloid leukemia”的研究论文,首次全面地揭示了NPM1突变的共突变特征谱(尤其是多种共突变组...
NPM1 mutation is one of the most common recurrent genetic lesions in AML, and is relatively specific for AML; it occurs in 2―8 % of childhood cases and 27―35 % of adult cases overall, as well as in 45―64 % of adult cases with...
In acute myeloid leukemia (AML), molecular heterogeneity across patients constitutes a major challenge for prognosis and therapy. AML with NPM1 mutation is a distinct genetic entity in the revised World Health Organization classification. However, differing patterns of co-mutation and response to ...
B). MLD is one of the diagnostic criteria defining AML with myelodysplasia related changes (AML-MRC) but, according to WHO classification, when it coexists withNPM1mutation,
Acute myeloid leukemia (AML) with NPM1 mutation is a distinct genetic entity with favorable outcomes. Nevertheless, emerging evidence suggests that NPM1-mu
[157]. The NPM1 mutant was sufficient to induce a myeloproliferative disorder, but was unable to generate AML recapitulating the phenotypic features observed in humans. Activation of a humanizedNPM1mutation in mouse HSCs was obtained using different conditional knock-in models, that allowed the ...
NPM1 is the most frequently mutated gene in AML and the role of the NPM1 mutant in acute myeloid leukemia along with its leukemogenic potential are still u... Sportoletti,Paolo - 《Pediatric Reports》 被引量: 7发表: 2011年 NPM1 mutation reprograms leukemic transcription network via reshaping...
Of note, at first remission, the role of allogeneic stem cell transplant (ASCT) in NPM1-mutated AML remains controversial as there is significant variation in practice. Historically, the benefit of ASCT was observed in patients with NPM1-mutated AML in the presence of FLT3 ITD; however, with...
Interestingly, DNMT3A was also the most frequent mutation in the NPM1 mut relapse cohort at diagnosis and persisted frequently during remission in this group. Mutated DNMT3A at diagnosis has been described in AML and is only moderately associated with outcome.9 The persistence of DNMT3A mutations...
同本病例类似,文献病例中的患者骨髓象主要特点为红系和粒系的病态造血,因原始细胞比例不高未诊断为AML,用地西他滨和维特克拉治疗后观察了外周血原始细胞变化,在治疗第57天时原始细胞达到20%以上,提示进展为AML。正是基于这样的研究结果,新分类标准中...