会议期间,医脉通特邀苏州大学附属第一医院陈苏宁教授接受采访,谈谈NPM1突变AML的相关进展。 医脉通:NPM1突变是急性髓系白血病(AML)中最常见的基因突变之一,在治疗决策中起着至关重要的作用,是AML预后良好的因素之一。您在本次大会中也...
尽管NPM1突变急性髓系白血病(AML)预后普遍良好,但许多患者仍会复发并死亡。据报道,许多分子生物学和临床特征与不良预后相关,包括年龄、白细胞计数(WCC)、继发性疾病、非ABD NPM1突变类型、NPM1突变负担和共突变。此外,现已经确定诱导化疗...
Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia (AML) and displays Cy localization in mutated nucleophosmin (NPMc+) AML. Here we show that NPM1 directly interacts with herpes virus-associated ubiquitin specific protease (HAUSP), which is known as a PTEN deubiquitinating enzyme...
我是一名54岁的女性,24年前被诊断出患有AML伴NPM1突变。经过第一次化疗后,我的病情得到了控制,出院回家休养。然而,在最近的血常规检查中,我发现C反应蛋白升高,纤维蛋白原和D二聚体异常。这让我非常担心,是否意味着我的病情复发了? 我决定寻求专业医生的帮助,于是通过互联网医院联系了一位经验丰富的医生。我们进...
Single-agent mezigdomide was efficacious in 5 patient-derived xenograft models of KMT2A-r and 1 NPM1c AML. The combination of mezigdomide with the menin inhibitor VTP-50469 increased survival and prevented and overcame MEN1 mutations that mediate resistance in patients receiving menin inhibitor...
急性髓系白血病(AML)最常见的分子异常是()A.FLT3突变B.NPM1突变C.C/EBPa突变D.AML1-ETO突变E.PML-RARα突变
百度试题 题目低危急性粒细胞白血病(AML)的标志是具有 A. C-KIT伴AML/ETO B. FLT3-ITD C. 仅有NPM1 D. WT1 E. MLL相关基因 相关知识点: 试题来源: 解析 C.仅有NPM1 反馈 收藏
NPM1-mutated AML: targeting by disassembling Inhis issueflood,alusundollegues provide preclinical evidenceshatargeting nucleophosmin (NPM1) induces differentiationnd deathfcuteyeloid leukemia (AML)ell... B Falini,MP Martelli - 《Blood》 被引量: 18发表: 2011年...
A rapid, one step assay for simultaneous detection of FLT3/ITD and NPM1 mutations in AML with normal cytogenetics. Huang Q, Chen W, Gaal K et al (2008) A rapid one step assay for simultaneous detection of FLT3/ITD and NPM1 mutations in AML with normal cyto... H Qin,W Chen,KK Gaa...
Bone Marrow Transplantation近日发表综述,评估了 MRD 监测在 NPM1 突变 AML 中的预后作用、监测方法和时间点,及其作为预测性生物标志物在优化风险分层和为治疗决策提供信息的作用,包括移植前 MRD 阳性对移植后结局的影响,以及移植相关因素(...