目前尚不清楚基线因素的影响是否完全通过MRD缓解获得,或者是否存在MRD阴性(MRD-)患者组,这些患者具有不良结局并需要不同的治疗策略。由于这些不确定性,NPM1mut AML的临床决策仍然具有挑战性和不一致性。为了解决这些问题,作者对两项连续前瞻性随...
研究者分析了在前瞻性试验中招募的大量NPM1突变AML患者,以阐明基线分子和临床特征、诱导治疗后MRD状态以及治疗强度对预后的影响。研究结果显示FLT3-ITD、DNMT3A、WT1和非ABD型NPM1突变均与较差的OS独立相关。这些因素还与MRD阳性密切相关。对于...
大约1/3的急性髓细胞白血病(AML)成人患者存在核磷酸蛋白(NPM1)突变。2024年1月,西班牙、英国、澳大利亚等国学者发表在《Blood Adv》的一项研究,考察了基于维奈克拉的低强度治疗用于分子失败的NPM1突变AML的有效性。 在NPM1突变AML中,如果不治疗,分子失败(在定量范围内(≥10−4)的持续可量化MRD阳性被定义为分子...
acute myeloid leukemia (AML)menin inhibitorsexportin 1XPO1 inhibitorsminimal residual disease (MRD)CAR-T cellsarsenic trioxideThe nucleophosmin 1 (NPM1) gene is mutated in approximately one-third of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (NPM1mut-AML) has been re...
“Those patients who were MRD-negative after chemotherapy did not derive any survival advantage from having a transplant in their first remission,” Othman said. MRD also predicts ASCT benefit in patients with NPM1-mutated AML and FLT3 ITD, which has traditionally been considered to be a strong...
patients with acute myeloid leukemia (AML) who harbored NPM1 mutations, had intermediate-risk cytogenetics at diagnosis, had a longer treatment duration, or a minimal residual disease (MRD) response during treatment, according to a survival analysis of the phase 3 QUAZAR AML-001 tr...
目的探讨NPM1突变阳性急性髓系白血病(AML)患者化疗后早期微小残留病(MRD)水平与预后的关系。 方法回顾性分析137例初治成人伴NPM1基因主要突变(A、B、D突变)AML患者的治疗结果,以及化疗后早期时间点MRD(NPM1突变转录本)水平对预后的影响。 结果在137例患者中,男67例(48.9%),中位年龄49(16~67)岁,染色体正常核型...
Acute myeloid leukemia (AML) with mutated NPM1 (Nucleophosmin 1) is a distinct entity in the 5th edition of the World Health Organization (WHO) Classificat
The presence of 2 or more CH-type mutations appears to predict a higher risk of relapse than a single mutation.38 Moreover, persistent DNMT3A-mutated hematopoiesis in NPM1-mutated AML patients in CR can engender the development of either NPM1− or NPM1+ relapsed AML, indicating that CH ...
Bone Marrow Transplantation近日发表综述,评估了 MRD 监测在 NPM1 突变 AML 中的预后作用、监测方法和时间点,及其作为预测性生物标志物在优化风险分层和为治疗决策提供信息的作用,包括移植前 MRD 阳性对移植后结局的影响,以及移植相关因素(...