nucleophosmin (NPM1) mutationacute myeloid leukemia (AML)menin inhibitorsexportin 1XPO1 inhibitorsminimal residual disease (MRD)CAR-T cellsarsenic trioxideThe nucleophosmin 1 (NPM1) gene is mutated in approximately one-third of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (...
NPM1 mutations appear to precede FLT3―ITD. AML with mutated NPM1 shows a distinct gene expression profile (characterized by upregulation of HOX genes) that differs from that of other AML types, including AML with KMT2A rearrangement. AML wit...
九、急性髓系白血病(AML)伴NPM1突变 AML with mutated NPM1 is characterized by high CD33 expression and variable (often low) CD13 expression. KIT (CD117), CD123, and CD110 expression are common. HLA―DR is often negative. Two...
B). MLD is one of the diagnostic criteria defining AML with myelodysplasia related changes (AML-MRC) but, according to WHO classification, when it coexists withNPM1mutation,
In addition, risk factors by gene mutation (NPM1/FLT3ITD) were assessed – with a pattern confirming high iASPP expression as an adverse survival factor (Supplementary Fig.S1). iASPP expression and clinical outcome in an independent clinical validation cohort ...
Detection of Gene Mutation Rate of CEBPa,NPM1 and FLT3-ITD in Patients with Acute Myeloid Leukemia in China 在线阅读 免费下载 引用 收藏 分享 摘要 目的:回顾性分析大量病例的基因检测结果,阐述CEBPa、NPM1及FLT3-ITD这三种最常见的AML突变基因在中国人群中的发生率。方法:本研究总共从全国25家医院收集了...
NPM1 or biallelic CEBPA mutations [1]. The classifcation of AML-MRC overlaps somewhat with the traditional term “secondary AML,” which includes patients with AML that develops from an antecedent hematologic disorder (includ ing MDS and MDS/MPN), as well as those with therapy related AML ...
Nucleophosmin (NPM1) gene mutations are reported to predict a favorable prognosis in acute myeloid leukemia (AML) patients. Aberrant cytoplasmic localization of nucleophosmin (NPM) protein is reported be a surrogate for NPM1 gene mutation. Using immunohistochemical (IHC) analysis, we assessed for NPM...
Mutations of the nucleophosmin (NPM1) gene have recently been described in patients with acute myeloid leukemia (AML). To clarify the prevalence as well as the clinical impact of this mutation, we investigated 1485 patients with AML for NPM1 exon 12 mutations using fragment analysis. A 4 bp ...
AML伴NPM1突变的特征是高CD33表达和可变的CD13表达(经常是低表达)。KIT(CD117),CD123,CD110为中等强度表达。HLA-DR通常阴性。AML伴NPM1主要有两组免疫表型,一组是幼稚髓系的免疫表型谱,另一组是单核系免疫表型谱(CD36+,CD64+,CD14+)。...