Wild-type NPM1 is normally localized to the nucleus, whereas mutant NPM1 proteins exhibit altered cytoplasmic localization. Clinically, AML with mutated NPM1 without FLT3 -ITD is associated with a higher complete remission rate and improved overall survival. AML with mutated NPM1 is categorized as...
NPM1突变是成人急性髓性白血病(AML)中最常见的复发性遗传异常。 该研究拟通过RT-qPCR方法检测MRD,并评估其在接受维奈克拉联合治疗的NPM1突变患者中的预后价值。 研究设计 患者入组标准为接受维奈克拉与低甲基化药物(HMA)或LDAC作为NPM1...
2024 EBMT OS1-07 EXCELLENT OUTCOME OF PATIENTS PROCEEDING TO ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION WITH UNTREATED MOLECULAR RELAPSE OF NPM1-MUTATED AML 声明本资讯旨在帮助医疗卫生专业人士更好地了解相关疾病领域最新进展。本公...
郑素洁 :根据WHO2016版(修订版)急性髓系白血病分型,这个患者诊断AML with mutated NPM1 茹进伟:请教一下NPM1突变的AML形态和流式有什么特点? 郑素洁 :之前看过一些文献,NPM1基因突变多见于正常核型的AML患者,M1和M5多见,患者高龄、高白,CD34和CD117低表达。 王哲:AML伴NPM1突变是2016版AML与相关肿瘤类型中的...
on this data, the ICC created this new category and elimi nated AML-MRC defned solely by morphologic dyspla sia and merged the prior category of AML with mutated RUNX1 into this group (Fig. 1). RUNX1 mutations in AML were already well known to be associated with prior therapy ...
郑素洁 :根据WHO2016版(修订版)急性髓系白血病分型,这个患者诊断AML with mutated NPM1 茹进伟:请教一下NPM1突变的AML形态和流式有什么特点? 郑素洁 :之前看过一些文献,NPM1基因突变多见于正常核型的AML患者,M1和M5多见,患者高龄、高白,CD34和CD117低表达。 王哲:AML伴NPM1突变是2016版AML与相关肿瘤类型中的...
AML with mutated NPM1 AML with the basic leucine zipper (bZIP) biallelic mutations of CEBPA Acute myeloid leukaemia with NUP98 rearrangement(FISH才能检测出,原始细胞亦被分为早幼粒细胞) <20%原始细胞亦可被诊断 Acute myeloid leukaemia with BCR::ABL1 fusion 16版是临时命名(≥20%) ...
Objective To investigate the effect of clonal hematopoiesis (CH) in remission on hematopoiesis recovery in patients with NPM1 mutated acute myeloid leukemi... 王淋淋,陈苏宁 - 《China Medical Abstracts:internal Medicine》 被引量: 0发表: 2024年 NPM1-mutated acute myeloid leukemia: New pathogenetic ...
Oral azacitidine was associated with improved long-term survival in patients with acute myeloid leukemia who harbored NPM1 mutations, had intermediate-risk cytogenetics at diagnosis, had a longer treatment duration, or a minimal residual disease response
第1期病例解析:伴NPM1突变AML的流式特点 急性髓系白血病(AML)伴NPM1突变,在WHO造血与淋巴组织肿瘤分类2008版中是暂定病种,2016版中升级为正式病种。 WHO造血与淋巴组织肿瘤分类2008(红色下划线): WHO造血与淋巴组织肿瘤分类2016(红色下划线): Acute myeloid le...