Jan Braune , Kathrin Rieger, et al. Relapse of NPM1-Mutated AML with Extramedullary Manifestation 17 Years after Allogeneic Hematopoietic Stem Cell Transplantation. Hindawi Case Reports in Hematology Volume 2022, Article ID 3317936, 3 pages...
Christopher, M.R., Nawas, M.T. & Reagan, J.L. Molecular measurable residual disease monitoring and transplant indications in NPM1 mutated acute myeloid leukemia. Bone Marrow Transplant (2024).
Wild-type NPM1 is normally localized to the nucleus, whereas mutant NPM1 proteins exhibit altered cytoplasmic localization. Clinically, AML with mutated NPM1 without FLT3 -ITD is associated with a higher complete remission rate and improved overall survival. AML with mutated NPM1 is categorized as...
AML with mutated NPM1 AML with the basic leucine zipper (bZIP) biallelic mutations of CEBPA Acute myeloid leukaemia with NUP98 rearrangement(FISH才能检测出,原始细胞亦被分为早幼粒细胞) <20%原始细胞亦可被诊断 Acute myeloid leukaemia with BCR::ABL1 fusion 16版是临时命名(≥20%) Acute myeloid leu...
郑素洁 :根据WHO2016版(修订版)急性髓系白血病分型,这个患者诊断AML with mutated NPM1 茹进伟:请教一下NPM1突变的AML形态和流式有什么特点? 郑素洁 :之前看过一些文献,NPM1基因突变多见于正常核型的AML患者,M1和M5多见,患者高龄、高白,CD34和CD117低表达。
on this data, the ICC created this new category and elimi nated AML-MRC defned solely by morphologic dyspla sia and merged the prior category of AML with mutated RUNX1 into this group (Fig. 1). RUNX1 mutations in AML were already well known to be associated with prior therapy ...
Figure 1. AML relapse with NPM1 mut occurs earlier than relapse with NPM1 wt. (A) RFS of patients with NPM1 mut relapse and NPM1 wt relapse. (B) OS following relapse of patients with NPM1 mut relapse and NPM1 wt relapse. 95% CI, 95% confidence interval; OS, overall survival; RFS...
郑素洁 :根据WHO2016版(修订版)急性髓系白血病分型,这个患者诊断AML with mutated NPM1 茹进伟:请教一下NPM1突变的AML形态和流式有什么特点? 郑素洁 :之前看过一些文献,NPM1基因突变多见于正常核型的AML患者,M1和M5多见,患者高龄、高白,CD34和CD117低表达。 王哲:AML伴NPM1突变是2016版AML与相关肿瘤类型中的...
NPM1-mutant protein degradation (ATRA/ATO, deguelin, (-)-epigallocatechin-3-gallate, imidazoquinoxaline derivatives) and at targeting the integrity of nucleolar structure (actinomycin D). We also discuss the current therapeutic results obtained inNPM1-mutated AML with the BCL-2 inhibitor venetoclax ...
【翻译】GATA2锌指基因1突变也与AML伴双等位CEBPA突变相关,可见于约39%的病例。 A subset of cases of AML with biallelic mutation of CEBPA have an abnormal karyotype. 【翻译】部分急性髓系白血病伴双等位CEBPA突变病例具有异常核型。 Similarly ...