2024年6月，《Circulation》杂志发表了一篇题为《Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism》的文章，该研究从表观遗传学角度出发，探索了核磷蛋白1（NPM1）在心肌梗死后心脏修复中的作用，为心肌梗死后的心脏修复提供了新的治疗策略。研究方法...
巨噬细胞根据其表型和功能可分为促炎型和修复型,后者在心肌梗死后的修复过程中起到关键作用。 2024年6月,《Circulation》杂志发表了一篇题为《Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparati...
The bone marrow was diffusely infiltrated by blast cells with starry sky pattern due to the presence of numerous tingible body macrophages (upper left, hematoxylin– eosin × 400; T, bone trabecula; the arrow indicates a macrophage). Macrophages were CD68+ (upper right, immunealkaline ...
2B). We found a significant increase in CD8+ T cells (cluster 4) and CD4+ T cells (cluster 7) in Npm1-deficient tumors; meanwhile, the macrophage (cluster 1 and 19) and myeloid-derived suppressor cell (MDSC) (cluster 17) populations were reduced (Fig. 2C). Since the recruitment and...
These analyses demonstrate a role for Npm1 in adult immune cells, and reveal the importance of translation regulation in macrophage function. Statement of significance Macrophages are a major component of the immune response to various insults including to cancer. Here we show that NPM1, the most...
positive for myeloperoxidase and macrophage-restricted CD68, and expressed cytoplasmic NPM1. TheNPM1mutation A was detected whilstFLT3was wild-type. The BM karyotype was normal. The patient, considered unfit for CHT, received venetoclax plus 5-azacytidine. She achieved MRD-positive CR after the firs...
Previous studies demonstrated that integration of the Csf2 gene into the genome of transgenic mice carrying the most prevalent phenotype of AML-related NPM1 mutation (NPMcA/−) could accelerate the onset of disease.15As Csf2 encodes the cytokine granulocyte macrophage colony-stimulating factor (GM...
(Fig.1d). However, there was a significant expansion of multi-lineage, mixed granulocyte/erythroid/macrophage/megakaryocyte (GEMM) colonies (Fig.1e), consistent with an expansion of multipotent stem and progenitor cells in the BM. Together, this data is generally consistent with human data ...
2024年6月,《Circulation》杂志发表了一篇题为《Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism》的文章,该研究从表观遗传学角度出发,探索了核磷蛋白1(NPM1)在心肌梗死后心脏修复中的作用,为心肌梗死后的心脏修复提供了新的治疗策略。
Immunofluorescence (IF) analysis of macrophage-infiltration in tumor tissues Tumor tissues were fixed by formalin and embedded using the Tissue-Tek O.C.T compound (#4583, Sakura). Samples were sectioned by a Cryostats apparatus (Leica). After washing with PBS buffer, and blocking with block so...