1.Patel SS, Kuo FC, Gibson CJ, Steensma DP, Soiffer RJ, Alyea EP, 3rd, et al. High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML. Blood. 2018;131(25):2816-25. 2.Heath EM, Chan SM, Minden MD, ...
NPM1 突变是监测白血病亚临床水平(即可测量的残留病,MRD)的理想靶点,因为它们是常见的 AML 特异性突变、在正常组织中不表达、在白血病前状态(如克隆性造血)中不存在;此外,它们与治疗反应、疾病复发时的复发和 MRD 水平升高(称为 MRD ...
NPM1mutated AML (NPM1mut-AML) has been reclassified as a distinct entity in the 2022 World Health Organization (WHO 2022) and European Leukemia Network (ELN 2022) classification on myeloid neoplasm requiring >10% of leukemic blasts for diagnosis. Clinically, it presents with high white ...
:这些急性髓系白血病在形态学上都有单核分化的特点,常需要根据细胞/分子遗传学加以鉴别。 预后:正常核型AML发生NPM1突变预后好,如合并FLT3-ITD突变则预后较差(至少在年轻人是如此),但还是比AML伴单纯FLT3-ITD预后要好。AML同时有NPM1、FLT3-ITD、DNMT3A突变...
Once aNPM1mutation has been recognized, the definitive diagnosis ofNPM1-mutated AML requires that other distinct and provisional AML entities of the 2017 WHO classification, such as AML-MRC (case 2), AML withBCR-ABL1(case 6, Fig.6) and AML withRUNX1mutations (Fig.6) are excluded. Accord...
to be a biomarker of poor prognosis. 1t can be dected in approximately 35% of AML patients and up to 60% of AML patients with normal cytogenetics. 1t is found that abnormal NPM1 has a huge impact on the biological diagnosis of hema...
MethodsRetrospective analysis was performed on 86 patients with NPM1 mut AML newly diagnosed and treated in the First Affiliated Hospital of Soochow University between July 2016 and June 2019. Their clinical data and NGS test results at diagnosis were analyzed. Moreover, bone marrow samples in remi...
Cytogenetics detection has become one of the main bases for the accurate diagnosis, treatment options and prognosis judgement of AML. However, the high heterogeneity at the molecular level leads to low detection rate by conventional cytogenetics detection technology. Clonal chromosome aberrations in ...
总之,APL在SSC减小的时候,与NPM1突变AML、KMT2A重排AML之间易混淆,但可以通过 CD2、CD13、CD34、CD64 和 MPO 进行区分。 信源:Fang H, Wang SA, Hu S, et al. Acute promyelocytic leukemia: Immunophenotype and differential diagnosis by flow cytom...