Notch signalling: a simple pathway becomes complex. Nature Rev. Mol. Cell Biol. 7, 678–689 (2006). Article CAS Google Scholar Kopan, R. & Ilagan, M. X. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137, 216–233 (2009). Article CAS PubMed PubMed ...
GENE-E/KEGG Notch signalling pathway InterProScan 4 (EMBL-EBI) Oncomine The Cancer Genome Atlas The Cancer Genome Atlas Data Portal US National Cancer Institute (clinical trials database) Glossary Signal-sending cell The cell on which the ligand is expressed. Canonical Notch signalling is...
GO and KEGG pathway enrichment analyses were conducted using DAVID online website. UBA6 knockout exacerbated MCAO-mediated brain injury and cell apoptosis in rat brain tissues by H&E and TTC staining and TUNEL assay. The results of flow cytometry and western blot assays further demonstrated that...
(B) Relative expression of 47 members of KEGG Notch signaling pathway gene set in passage 2 SGOs from a patient taking β-blockers, compared with mean of expression in six no-medication controls. Notch ligand, receptors, and downstream targets are highlighted in colors stated. (C) Representativ...
The PI3K Signaling Pathway 01:50 The MAPK Signaling Pathway 01:54 The MAP Kinase (MAPK) signalling pathway 05:06 Smad Pathway 05:07 Apoptotic Pathways 02:05 TGF Beta Signalling Pathway 06:01 Hippo Signaling Regulates : miRNA Biogenesis to Cancer 05:18 Hippo Pathway: YAPing Hippo Forecasts new...
Kyoto encyclopedia of genes and genomes (KEGG) analysis showed that a number of pathways, including ubiquitin mediated proteolysis, PPAR signaling pathway, and mammalian target of rapamycin (mTOR) signaling pathway were predominantly over-represented. Meanwhile, overexpression of Notch1 suppressed and ...
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses on (A) total differentially expressed genes (DEGs) identified in EIIa;NOTCH2NLC-(GGC)98 (EIIa-tg for short) mice, (B) total DEGs identified in Myh6;NOTCH2NLC-(GGC)98 (Myh6-tg for short)...
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Fig. 5: Loss of MYL3 promotes the activation of Notch signaling and induces senescence by enhancing CME. aVolcano plot of RNA-seq of primary chondrocytes from control andMyl3-KO mice. The dotted line denotesP = 0.05.bTop 10 pathway enrichment of KEGG pathway analysis followingMyl3knock...
1a). KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis showed that the top 20 enriched pathways included the glycolysis pathway (Fig. 1b). Next, we investigated the effect of Notch1 on the glycolysis pathway. The expression of glycolysis-associated genes LDHA, PFKB3, PKM2, PGK1, HK2...