[2]Bray SJ.Notch signalling:a simple pathway becomes complex.Nat Rev Mol Cell Biol.PMID:16921404. [3]Robert-Moreno A,Espinosa L,etc.RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development.PMID:15689374. [4]Weng ...
NOTCH signaling pathwayNOTCH genesEMBRYOLOGYINVERTEBRATESRESEARCH personnelThe highly conserved Notch signaling pathway affects embryonic development, neurogenesis, homeostasis, tissue repair, immunity, and numerous other essential processes. Although previous studies have demonstrated the location and function of ...
The function of the Notch intracellular domain (NICD) is central to Notch-mediated regulation of chondrogenesis. The NICD, one of the end products of the Notch signaling pathway, translocates into the nucleus where it complexes with CSL-type DNA binding proteins CBF1(RBP-J), Su(H), and Lag...
The Notch signaling pathway plays a crucial role in regulating cell fate decisions under physiological conditions, influencing cell proliferation, differentiation, development, and homeostasis. However, dysregulation of the Notch signaling pathway has been increasingly observed in various human malignancies,54,...
[2]Bray SJ.Notch signalling:a simple pathway becomes complex.Nat Rev Mol Cell Biol.PMID:16921404. [3]Robert-Moreno A,Espinosa L,etc.RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development.PMID:15689374. ...
Notch signaling pathway.Image Credit: Ellepigrafica / Shutterstock 临床前研究中,研究人员选择了9例TNBC模型。 其中,4例模型具有Notch激活突变或融合(Notch-on),2例具有野生型Notch,其余具有预期不会诱导激活的Notch突变。 结果显示:仅在具有Notch-on特征的模型中观察到肿瘤生长的显著抑制。具体而言,AL101在具有Notc...
The regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive effects. Moreover, the Notch signaling pathway is implicated in conferring chemoresistance to tumor cells. Therefore...
researched.ThisreviewdescribesthefunctionofNotchsignalingpathwayintumorstemcellsanddrugresearchesaimed atNotchsignalingpathway. Keywords:Notchsignalingpathway;tumorstemcell;inhibitor 1Notch信号通路概述 1917年,Morgan等在果蝇体内发现Notch基 因。Notch的受体和配体均为单次跨膜蛋白,其有 ...
[1]Zhou B H, Lin W L, Long Y L, et al. Notch signaling pathway: architecture, disease, and therapeutics[J]. Signal Transduct Target Ther, 2022, 7(1): 95. [2]王雪淞, 周林, 李林材, 等. Notch信号通路调控间充质干细胞的增殖与分...
1 Notch signaling transduction pathway 麦文豪等 Notch 信号通路在感染过程中对免疫应答的调控作用 第 4 期 ·873· 1 Notch 信号通路在免疫细胞发育 、分化 和激活中的作用 关于Notch 信号对免疫细胞的作用,研究较多 的是淋巴细胞尤其是胸腺 T 细胞和脾脏边缘区 B 细胞(marginal zone B cell,MZB)发育过程[3...