We postulated that the Notch signaling pathway, known for its role in cellular differentiation and binary cell fate choice, acts as a key player in the MPEC/SLEC differentiation choice. To elucidate the role of Notch signalling, we have analyzed CD8 T cell response in mice lacking or not the...
The Notch signaling pathway, which is highly conserved across species, is implicated in numerous aspects of cancer biology, including the cancer stem cell phenotype, tumor angiogenesis, metastasis, and tumor immune evasion [1,2,3,4,5]. After decades of study, scientists have revealed that Notch ...
[translate] aFind your wireless carrier and see your service options 发现您的无线载体并且看您的服务选择[translate] aDo you volume. 做您容量。[translate] aThe Notch signaling pathway 山谷信号路[translate]
4. How Ubiquitinations Regulate Notch Pathway 4.1. NIC Stability The first ubiquitination step identified in Notch signaling concerns the regulation of NIC stability. Notch intracellular domains exhibit canonical PEST domains (rich in proline, aspartic acid, serine and threonine residues), which are as...
The Notch signaling pathway regulates many aspects of embryonic development, as well as differentiation processes and tissue homeostasis in multiple adult organ systems. Disregulation of Notch signaling is associated with several human disorders, including cancer. In the last decade, it became evident ...
Fig. 1. An overview of Notch signaling pathway in SCLC, Notch signaling is conducted through Notch receptors and DSL family ligands. Canonically, the Notch receptor undergoes seven steps to activate the Notch signaling pathway: 1) Synthesis in ER; 2) S1 cleavage by a furine-like convertase in...
et al. NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am. J. Hum. Genet. 79, 169–173 (2006). Article CAS PubMed PubMed Central Google Scholar Garg, V. et al. Mutations in NOTCH1 cause aortic valve disease. Nature 437, 270–274 (...
Notch signaling pathway: architecture, disease, and therapeutics Article Open access 24 March 2022 References Ellisen, L. W. et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649–661 (1991). NOTCH...
研究点推荐 Notch signaling cochlear epithelium Notch signaling pathway 引用走势 2016 被引量:1 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解更多>> ...
In addition, in the light of current interest in developing cell-based therapies, Notch signalling may become an attractive target for manipulating the outcome of cell fate decisions to produce defined cell types in vitro. The involvement of many enzymatic steps in the Notch pathway provides much ...