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We hypothesized that cells present in normal tissue that bear cancer stem cell markers may represent a cancer cell of origin or a microenvironment primed for tumor development, and that their presence may correlate with the clinically defined subtypes of
(enterocytes, goblet cells and endocrine cells), and most colorectal cancers.27 MUC2 is a goblet cell marker seen in various degrees of differentiation from basal pre-goblet cells to mature goblet cells.28,29 Both CK20 and MUC2 are used diagnostically in colon cancer to help determine if a ...
Blood samples containing elevated numbers of CD34-positive hematopoietic progenitor cells were obtained from nonhematologic cancer patients undergoing autologous bone marrow transplantation and receiving recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) after myeloablative chemotherapy.18...
The aorta contains numerous cell types that contribute to vascular inflammation and thus the progression of aortic diseases. However, the heterogeneity and cellular composition of the ascending aorta in the setting of a high-fat diet (HFD) have not been
Hemoglobin levels that fall below the normal range can be a sign of certain health conditions such as cancer or anemia. When your hemoglobin is low, your body can’t get enough oxygen to its tissues, and it makes you feel tired and weak. ...
oral cancerperiodontal ligamentperiradicular granulomavascularityAim To quantify vascularity in periradicular granulomas using different endothelial markers, and assess its value as an index of angiogenesis by comparing granulomas with healthy periodontal ligament (PDL). To use oral tumours, compared with ...
Distinct cell populations and their expression signatures.A. CNV was performed to identify the colorectal cancer cells.B. tSNE plot of all the cells based on different cell types and clusters.C. tSNE plot of all the cells based on different stages and clusters.C. The marker genes in each ce...
Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division. However, in some cancers, defective proofreading due to acquired POL
The process of organ development requires a delicate balance between cellular plasticity and differentiation. This balance is disrupted in cancer initiation and progression. N-Myc and STAT interactor (NMI: human or Nmi: murine) has emerged as a relevant player in the etiology of breast cancer. How...