Nerve cells in the brain and throughout the body can turbocharge tumor growth — a finding that not only expands conventional ideas about the nervous system but points to novel therapeutic targets for a range of malignancies.大脑和全身的神经细胞可以加速肿瘤生长--这一发现不仅拓展了人们对神经系统的...
Int J Biol Markers. 2000;15(2):147–52. Article Google Scholar Wilder JL, Pavlik E, Straughn JM, Kirby T, Higgins RV, DePriest PD, et al. Clinical implications of a rising serum CA-125 within the normal range in patients with epithelial ovarian cancer: a preliminary investigation. ...
(ICB). To identify improved predictive markers together with cTMB, we performed whole-exome sequencing for 104 lung tumors treated with ICB. Through comprehensive analyses of sequence and structural alterations, we discovered a significant enrichment in activating mutations in receptor tyrosine kinase (...
The purpose of this study was to investigate the use of thromboelastography (TEG) in patients with colorectal cancer and to examine whether the TEG parameters can be used as potential markers for disease screening and prediction of disease severity. One-
Recurrent germline copy number variations (CNVs) were identified across all DNA samples from normal tissue, and markers within these regions (representing ∼15% of all markers) were removed from further analysis. Noise was further reduced by application of Tangent normalization followed by circular ...
The discovery of CAR-T cells in the preclinical stage was based on in vitro co-culture assays and in vivo xenograft mouse models. Although these conventional assays could be used to evaluate the expression of cell surface markers, cytokine secretion, and cancer cell killing, the spectrum of ind...
BP biological progress, CC cellular component, MF molecular function is downregulated compared to that in normal samples, suggesting that it may be a more potential biomarker of gastric cancer than the common tumor markers CEA and CA19-9 [23]. Liu et al. attempted to construct the ...
transformed expression levels of the cell type markers (s100, mitf , cd3 , and cd8). we applied the em algorithm for mixtures of normal distributions to characterize the two normal distributions for each of these cell type marker intensities. s100 + /mitf + /cd3 - /cd8 - cells were ...
Also the cell shape could be taken into account as it plays an important role in interactions between cells and mE factors, particularly when the cell density is high and causes shape deformation and cell-cell interaction through cell surface markers. On the other hand, relevant regulatory or ...
To evaluate the MAGE-A6 and MAGE-A11 expressions and their clinical relevance, the expression of these markers was determined in 199 and 213 BC tissues, respectively. Overall, the median age of the study population both MAGE-A6 and MAGE-A11 expression was 67 years (range 20–95). The study...