Figure 6 Pie chart summarizing the most relevant biological processes associated with the cancer marker proteins, grouped in seven major categories: signaling, DNA repair, redox processes, metabolism, proliferation/apoptosis, immune response, and adhesion/migration. Full size image...
RPPH1 promotes CRC cells metastasis by binding to TUBB3, thus inhibiting its ubiquitination and enhancing exosomes-mediated macrophages M2 polarization and influences the tumor microenvironment (Fig. 7g). Moreover, plasma exosomal RPPH1 may be a diagnostic marker and a therapeutic target in CRC....
survivin/mTOR inhibition strategy was mediated by decreasing survivin levels with the corresponding induction of apoptosis [32]. The authors proposed that survivin inhibition as a novel approach to improve RCC therapy warrants further investigation [32]. However, use of YM155 to address survivin’s r...
similar to the previously reported iCAFs in various types of tumors such as BC [6] and PTC [8]. GO enrichment analysis of its marker genes showed their association with the response to mechanical stimulation, reactive oxygen species, epithelial cell proliferation, immune system, and...
A potential limitation of this and other reports is the use of CD11c expression as the exclusive marker to identify TIDCs, which may include a majority of TAMs in the subsequent functional analyses [93]. Recent reports refining the isolation of cDC1 from the tumor site confirmed that these ...
[194,245,246]. Traditional CAR-T cell studies use in vitro and in vivo experiments to assess cell surface marker expression, cytokine secretion, and tumor cell killing. However, these assays do not fully reflect the effect of T cell immune surveillance and its interactions with the TME [243...
Elevated YTHDF1 levels are associated with increased NOTCH1 expression, a tumor stem cell marker, and enhanced HCC stemness, which can lead to drug resistance [8]. In vivo studies show that YTHDF1 siRNA delivered via nanoliposomes significantly suppresses HCC growth and enhances the efficacy of...
The expression of some marker genes we showed was plotted using FeaturePlot and VlnPlot function in Seurat (Butler et al., 2018) R package. The pathways we showed in dot plot was plotted using ggplot2 (Wickham, 2016) R package. Quantification and statistical analysis Asterisks in the figures ...
3C). These results suggest that DUSP16 may have similar function in NPC, CRC, and gastric cancer in response to various chemotherapeutic agents and the level of DUSP16 could serve as a marker for sensitivity to chemotherapy in these cancers. To further elucidate the function of DUSP16 in ...
In the marker paper15, this work provided the largest collection of uniformly processed cancer whole genomes to date with germline and somatic variants from reanalyzed sequencing data aligned to the human genome (reference build hs37d5) using standardized and highly accurate pipelines. Recent work ...