Personalized cancer medicine promised the ability to improve cancer treatment using molecular marker(s) (e.g. genome sequence, gene expression) obtained from the patient’s tumor. There have been some notable successes, for example, tyrosine kinase inhibitors in BCR-ABL1 positive chronic myeloid leu...
740 genes) in 16 PCAWG cohorts explained by different methods (size of each cohort reported in Supplementary Table1). Box plot elements are defined inMethods.e, Approximate numbers of false-positive and true-positive driver genes
Introduction The development of secondary tumors in a part of the body that is far from the original primary cancer is termed “metastasis.” Despite metastasis being the key cause of failure of cancer therapy and mortality, it remains poorly understood. In patients with cancer, large numbers of...
They revealed that this miRNA is downregulated in CD44+ cells derived from both patients and xenografts (10–80% of expression of the corresponding marker-negative populations). Overexpression of miR-141 diminishes cancer stem cell features, including self-renewal. In vivo, miR-141 inhibits tumor ...
The PSA-TRICOM platform employs a strategic approach wherein it enables the expression of prostate-specific antigen, a marker for prostate cancer while incorporating three T cell receptor-stimulating co-regulators (TRICOM). This incorporation facilitates the activation of previously dormant DCs and T ...
Johnny’s alkaline phosphatase (ALP) has also decreased from 208 to 165. ALP is associated with bony metastasis. An elevated ALP is a prognostic marker for poorer survival in metastatic cancer. Johnny started to take the herbs on 10 October 2022. So from the blood results – PSA, platelet ...
Even the normal and mundane things in life can often throw up a reminder of your cancer when you’re least expecting it. Now, every time I go on holiday, I beep as I go through the airport scanner. This is because of the metal marker clips put in my breast where the tumour site wa...
A metabolic steady state may only represent a temporary marker prior to more complete collapse, thermodynamic as well as economic, given the severe constraints hyperinflation would impose on modern society. Along the pathway of contraction, any external resources that become available to civilization wou...
A metabolic steady state may only represent a temporary marker prior to more complete collapse, thermodynamic as well as economic, given the severe constraints hyperinflation would impose on modern society. Along the pathway of contraction, any external resources that become available to civilization wou...
I feel that the decisions that I have made in personally fighting my cancer have been beneficial (I lost a lot of weight when I eliminated dairy and cancer nodules on my liver disappeared; the Louse Hay book that I bought really seems to help and my cancer marker levels are falling) but...