(1)cicrRNAs作为内源mRNA的竞争者,是miRNA的海绵吸附体 内源竞争性RNAs(ceRNAs)包括mRNAs,假基因,lncRNA,可以竞争性结合miRNA。因此,ceRNAs的存在影响miRNAs的功能活性。最近的研究表明circRNAs可作为miRNA的海绵吸附体,也是ceRNAs分子之一。比如,ciRS-7/CDR1as 和Sry可以结合miRNAs而不被降解,可能是潜在...
However, these strategies under-represent many biologically relevant classes of small noncoding RNAs in the 36-200 nucleotides length range (tRNAs, snoRNAs, etc.). To address this, we developed DANSR, a tool for the detection of annotated and novel small RNAs using sequencing reads with ...
location[1].ApproximatelyhalfoftheECcasesthatarenewlymanylongnoncodingRNAs(lncRNAs)aredysregulatedin diagnosedeachyearoccurin[2].Histologically,esophagealvariouscancersandthattheselncRNAsplayimportantrolesin squamouscellcarcinoma(ESCC)andesophagealadenocarcino-tumorigenesisandtumorprogression[7–9].Oneexampleofsuch ...
The structure of aeukaryoticprotein-codinggene. Regulatory sequence controls when and where expression occurs for theprotein coding region(red).Promoterandenhancerregions (yellow) regulate thetranscriptionof the gene into a pre-mRNA which ismodifiedto removeintrons(light grey) and add a 5' cap and ...
These small RNAs are often lost during traditional RNA isolation methods. In addition, this kit includes reagents and instructions for the isolation of RNA that is enriched for small RNA (<200 bp), enabling more sensitive detection of low-level small RNAs. mirVana...
(1)cicrRNAs作为内源mRNA的竞争者,是miRNA的海绵吸附体 内源竞争性RNAs(ceRNAs)包括mRNAs,假基因,lncRNA,可以竞争性结合miRNA。因此,ceRNAs的存在影响miRNAs的功能活性。最近的研究表明circRNAs可作为miRNA的海绵吸附体,也是ceRNAs分子之一。比如,ciRS-7/CDR1as 和Sry可以结合miRNAs而不被降解,可能是潜在...