AIMS. Gliomas are traditionally separated into low-grade (LGG) and high-grade (HGG). As LGG are slower growing and with pressures on operating capacity, there is an argument that surgery for these patients can wait. Pre- operatively, contrast enhancement on imaging is usually taken as the ...
Objective: The management of non-contrast-enhancing brain tumours largely depends on biopsy, which allows a differentiation of low-grade gliomas (LGG) from high-grade gliomas (HGG). The aim of this study was to compare positron emission tomography using 2-[ 18 F]-fluoro-2-deoxy- d -glucose...
Our purpose is to evaluate the value of MR perfusion weighted imaging (PWI) and diffusion tensor imaging (DTI) in differentiating between low grade and high grade non-enhancing supratentorial gliomas. METHOD AND MATERIALS 37 patients with pathology confirmed non-enhancing supratentorial glioma, whose ...
Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group. J. Clin. Oncol. 2010, 28, 1963–1972. [Google Scholar] [CrossRef] [PubMed] Teske, N.; Karschnia, P.; Weller, J.; Siller, S.; Dorostkar, M.M.; Herms, J.; von ...
indicating the previously unrevealed therapeutic strategy of targeting the BRPF1 mutation and Kpr in cancers [74]. Histone deacetylase inhibitors (HDACis), as antitumour drugs, can induce not only histone Kac but also Kpr in glioma cells, suggesting that Kpr may be measured to monitor HDACi ph...
Although non-enhancing lesions suspicious for glioma are usually assumed to be low grade glioma (LGG), some high grade glioma (HGG) do not enhance, which may lead to a delay in biopsy and/or resection, diagnosis, and treatment initiation. Thus, there is a clear need for a large-sample ...
Nonenhancing gliomasOligodendrogliomasBackground: Contrast enhancement in a brain tumour MRI is typically indicative of a high-grade glioma. However, a significant proportion of non-enhancing gliomas can either be grade II (GII) or grade III (GIII). Whilst gross total resection remains the primary...
rCBV estimates for high-grade gliomas are artificially changed by contrast extravasation through a disrupted blood-brain barrier (BBB). Moreover, with an intact BBB in non-enhancing tumor, the DSC signal intensity would not recover to its baseline level due to steady-state agent distribution. In...
OBJECTIVE: The management of non-contrast-enhancing brain tumours largely depends on biopsy, which allows a differentiation of low-grade gliomas (LGG) from high-grade gliomas (HGG). The aim of this study was to compare positron emission tomography using 2-[(18)F]-fluoro-2-deoxy-D: -glucose...
Objective Amide proton transfer (APT) weighted chemical exchange saturation transfer (CEST) imaging is increasingly used to investigate high-grade, enhancing brain tumours. Non-enhancing glioma is currently less studied, but shows heterogeneous pathophysiology with subtypes having equally poor prognosis as ...