high-grade英 /'hai'ɡreid/ 美 /'hai'ɡreid/ 释义adj. 高级的;优质的 例句The trial's preliminary results indicate the vaccine was associated with tumor-specific immuneresponse in patients with recurrent,high-gradeglioma. 研究结果初步显示疫苗可使复发的恶性胶质瘤患者产生肿瘤特异性免疫反应。
Recent genomic studies of pediatric high-grade gliomas (pHGGs) have unraveled important new clues into the pathogenesis of these tumors. One novel insight that was previously unappreciated is the role of epigenetic alterations in pediatric gliomagenesis. This was realized when mutations in histone 3.3...
Twenty patients (median age: 14 years) were treated. All were evaluable for response and toxicities. The most frequent diagnoses were high-grade glioma (HGG; n = 7) and rhabdomyosarcoma (n = 7). Twenty-one actionable mutations were detected: hotspot mutations in KRAS (n = 8), NRAS (n ...
Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumor...
Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in children. In vitro and in vivo disease models reflecting the intimate connection between developmental context and pathogenesis of pHGG are essential to advance understa
Pediatric High Grade Glioma 来自 Springer 喜欢 0 阅读量: 21 作者: C Sarkar,S Purkait,P Pathak,P Jha 展开 摘要: Pediatric high grade gliomas (pHGGs) constitute about 20% of childhood gliomas and show poor survival. The underlying molecular pathogenesis of pHGGs is significantly ...
Although the prognosis for survival of supratentorial high-grade glioma is not as ominous in children as in adults, this survival advantage may be in part a result of stronger constitution of children as well as differences in the molecular genetic substrate of the neoplasm....
high-grade astrocytoma HGG: high-grade glioma H3.3: histone 3.3 MAPK: mitogen-activated protein kinase NSC: neural stem cell PA: pilocytic astrocytoma RTK: receptor tyrosine kinase TCGA: The Cancer Genome Atlas YB-1: Y-box protein 1
High Grade Glioma Imaging Immune-, Cell-, Gene-, and Viral-Based Therapies Low Grade Glioma Medulloblastoma Neurofibromatosis and other Cancer Predisposition Syndromes Neuropsychology, Quality of Life, Survivorship Neurosurgery, Drug Delivery Nursing, Social Work, Patient Support ...
High Grade Glioma Imaging Immune-, Cell-, Gene-, and Viral-Based Therapies Low Grade Glioma Medulloblastoma Neurofibromatosis and other Cancer Predisposition Syndromes Neuropsychology, Quality of Life, Survivorship Neurosurgery, Drug Delivery Nursing, Social Work, Patient Support ...