The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension. We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that...
The G allele was also independently associated with insulin resistance, impaired pancreatic β cell function, and incretin effect during the OGTT.In NASH, the LOX-1 polymorphism is associated with liver disease severity and may predispose to CVD through modulation of postprandial small TRLPs and ...
Chromosomal Allele Loss in Primary Cutaneous Melanoma is Heterogeneous and Correlates with Proliferation Loss of heterozygosity at specific loci in neoplastic cells suggests the presence of a tumor suppressor gene within the deleted region. Using the microdiss... R Böni,D Matt,A Voetmeyer,... -...
did not observe a statistically significant joint effect of cooking oil fume and 399Gln or -77C variant allele on lung cancer among women nonsmokers. In... M Li,Z Yin,P Guan,... - 《Lung Cancer》 被引量: 192发表: 2008年 Environmental tobacco smoke and breast cancer incidence To evalua...
More mismatching also had no detrimental effect on event-free survival (on multivariate analysis, HR = 0.60, P = .03 for 3-4 vs fewer antigen mismatches and HR = 0.55, P = .03 for 3-4 vs fewer allele mismatches). Thus, greater HLA disparity does not appear to worsen overall outcome...
Furthermore (Perez et al., 2010) demonstrated an association between high levels of expression of TNF-α allele and susceptibility of dengue hemorrhagic fever (DHF). Another important cytokine in DENV infection is macrophage migration inhibitory factor (MIF). Assuncao-Miranda et al. (2010) showed...
The C allele of intron polymorphism rs1871054 carried risk for advanced rKOA, mostly to osteophyte formation in TFJ in males (OR 3.03; 95% CI 1.11-7.53, P = 0.018). Also the CCAA haplotype of ADAM12 was associated with osteophytosis, again mostly ...
The single nucleotide polymorphism occurs at both alleles of the hTERT gene in about 10% of the patients, and at a single allele in about 53% of the patients (33). Consistent with EtsA mediation of Ets2 regulation of telomerase activity, the –245Thr → 245Cys polymorphism correlates with...
Combined effect of a null allele and a non-collagenous insertion in COL1A1 mRNA is responsible for the severe phenotype in a family affected by osteogenesis imperfectastable carbon isotopesseagrassesisotope signaturesvariabilityIn this article we study the effects of heterogeneity on the spread of HIV...
In the patient group, the G allele was 261 (52.63%) and the C allele was 235 (47.37%), whereas in the control group, the G allele was 56 (34.54%) and the C allele was 106 (65.43%). In our study, 53 out of 174 women had GG allele and 54 out of 155 men had GG allele....