A huge diversity of noncoding RNAs (ncRNAs), which lack the protein-coding ability, are transcribed from the mammalian genome. The ncRNAs act as important mediators for target gene expression by regulating the levels of transcription, translation, and degradation. Among the known ncRNAs, microRNAs ...
RNA 21, 1122–1134 (2015). 25. Shen, Z. et al. Long non-coding RNA profiling in laryngeal squamous cell carcinoma and its clinical significance: potential biomarkers for LSCC. PLoS O# 9, e108237 (2014). 26. Yan, X. et al. Comprehensive genomic characterization of long non-coding RNAs...
Long non-coding RNAs (lncRNAs) form a new class of RNA molecules implicated in various aspects of protein coding gene expression regulation. To study lncRNAs in cancer, we generated expression profiles for 1707 human lncRNAs in the NCI60 cancer cell line panel using a high-throughput nanowell R...
We used three siRNAs (siRNA-205, siRNA-318, and siRNA-2423) to knockdownCIWIin PGCs using RNA transfection. Approximately 48 h after transfection, all three siRNAs significantly decreased the expression ofCIWI: 50% decrease by siRNA-205, 47% by siRNA-318, and 66% by siRNA-2423 (Figure4B)...
LncRNA Sequencing Employing reverse transcription methods to transcribe lncRNA into cDNA, determining the sequences of specific segments, and using RACE methods to determine the sequences at both ends. Inquiry LncRNA Expression Profiling Analysis Service Employing high-throughput sequencing technologies to...
Genome-wide small noncoding RNA profiling of pediatric high-grade gliomas reveals deregulation of several miRNAs, identifies downregulation of snoRNA cluster HBII-52 and delineates H3F3A and TP53 mutant-specific miRNAs and snoRNAs Int. J. Cancer, 137 (2015), pp. 2343-2353 CrossrefView in Scop...
A Salmonella Small Non-Coding RNA Facilitates Bacterial Invasion and Intracellular Replication by Modulating the Expression of Virulence Factors Small non-coding RNAs (sRNAs) that act as regulators of gene expression have been identified in all kingdoms of life, including microRNA (miRNA) and small ...
6. Targeted RNA Sequencing Reveals the Extraordinary Depth and Complexity of the Transcriptome Highlight by John S. Mattick Transcriptional profiling is bedeviled by the domination of the data by highly expressed RNAs, which means that cell- or stage-specific transcripts are undersampled, especially ...
However, the potential role of long noncoding RNA (lncRNA) in the osteogenic differentiation of human MSCs remains largely unclear. Here, we undertook the survey of differential coding and noncoding transcript expression profiling and functional network analysis during osteogenic differentiation of human...
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