Long noncoding RNALncRNAlincRNAMicroarrayGene expression profilingArraystar LncRNA microarrays are designed for global gene expression profiling of both LncRNAs and mRNAs on the same array. The array contents feature comprehensive collections of LncRNAs and include entire sets of known coding mRNAs. Each...
Microarray is a well-established method to profile both miRNAs and lncRNAs, although it was initially designed for protein-coding mRNAs. This technology is based on nucleic acid hybridization between labeled RNA targets and their specific and complementary probes. Advantages of microarrays are the high...
miRNA microRNA lncRNA long non-coding RNA RV Resveratrol GO Gene Ontology EMT Epithelial to Mesenchymal Transition TCGA The Cancer Genome Atlas 1. Introduction Ovarian cancer remains among the deadliest gynecological cancer in women worldwide. Based on a recent statistic, it is predicted that in 20...
In the current study, we intended to explore the role of long non-coding (lnc) RNAs in this transitional stage. We analyzed lncRNA expression profiles in mouse hearts at postnatal day (P) 1, P7 and P28 via microarray. We identified 1,146 differentially expressed lncRNAs with more than 2.0...
Non-coding RNAs (ncRNAs) are an essential class of molecular species that have been difficult to monitor on high throughput platforms due to frequent lack ... JC Castle,CD Armour,M Löwer,... - 《Plos One》 被引量: 218发表: 2010年 A Salmonella Small Non-Coding RNA Facilitates Bacterial...
[34] Human Exon 1.0 ST array showHOTAIRM1as the only lncRNA with significantly increased expression in glioblastomas with chromosome 7 gain in addition to the coding genesEGFR, MEOX2andSEMA3A. Log rank analysis for Kaplan–Meier survival plots; ***p < 0.001, **p < 0.01, *p ...
[2]. The roles of functional RNAs, including mRNA, ribosomal RNA (rRNA), and transfer RNA (tRNA), were first identified in the process of protein synthesis. While mRNAs, which carry the genomic information for protein-encoding, are referred to as coding RNAs, non-coding RNAs (ncRNAs), ...
Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, we used a custom microarray to identify lincRNAs associated with activation of the innate immune response...
(lncRNAs) which are characteristically more than 200 nucleotides long and can be transcribed from both protein-coding (e.g.H19and) as well as non-coding DNA by RNA polymerase II. The lncRNAs do not have open reading frames (with some exceptions), 3`-untranslated regions (3’-UTRs) and ...
Microarray analysis of lncRNA and mRNA expression An Arraystar Human LncRNA Microarray V3.0 (Array-Star, Inc., Rockville, MD, USA) was employed in this study. This array contains 30,586 LncRNA probes and 26,109 coding transcript probes, and it was constructed using the most authoritative pub...