Other factors, such as WNT and its non-canonical WNT5a-inducing pathway, are relevant in inflammation, cell migration, and neoangiogenesis. Thus, we studied circulating monocytes from untreated severe psoriatic patients and characterized inflammatory cytokines, chemokines, mTOR act...
The non-canonical Wnt pathway negatively regulates dendritic cell differentiation by inhibiting the expansion of Flt3 (+)lymphocyte-primed multipotent precursors. Xiao J,Zhou H,Wu N,et al. Cellular and molecular immunology . 2015Xiao J, Zhou H, Wu N, et al. The non-canonical Wnt path- way ...
These findings suggest that the non-canonical pathway may have a more prominent role in lung cancer than previously reported 展开 关键词: WNT pathway lung cancer gene expression NSCLC non-canonical squamous cell carcinoma DOI: 10.4137/CMO.S612 被引量: 64 ...
The hierarchical clustering showed a regular pattern of genes of the canonical and non-canonical Wnt pathways randomly distributed throughout the dendrogram. Our data reinforce previous reports suggesting no activation of canonical Wnt pathway in pituitary tumorigenesis. Moreover, we describe, for the ...
In this study, we show that the non-canonical Wnt pathway plays a crucial role in maintaining the quiescent status of NSCs during both normal and pathological conditions. Non-canonical Wnt signaling, through the activation of Rho-GTPase Cdc42, maintains NSC adhesion to the apical niche and ...
cWnt is associated with adverse prognosis (DFS p = 0.0469; OS p = 0.004891) but its prognostic role is indifferent in carcinoma with nWnt activated. Conclusions Canonical Wnt pathway is involved in malignant progression with dominant role for vascular invasion whereas non canonical Wnt pathway ...
Wnt signalling is mediated through cell鈥揷ell interaction and is involved in many developmental processes and cellular functions. In this study, we investigated the possible function of Wnt5a and the non-canonical Wnt pathway in human endothelial cells. We found that Wnt5a-mediated non-canonical ...
Interestingly, these different Wnt pathways use distinct beta-catenins to control POP-1 function: the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated kinase (MAPK) pathway to downregulate POP-1, whereas the canonical Wnt pathway employs the ...
Wnt signaling is widely recognized as essential for normal and cancer stem cell. Moreover, β-catenin-dependent Wnt pathway, referred to as canonical, has gained attention, while β-catenin-independent Wnt pathways, known as non-canonical, have remained conspicuously less explored. However, recent ...
Ovarian cancer (OC) can be classified into five biologically distinct molecular subgroups: epithelial-A (Epi-A), Epi-B, mesenchymal (Mes), Stem-A and Stem-B. Among them, Stem-A expresses genes relating to stemness and is correlated with poor clinical pro