The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem Biophys Res Commun 2003 ; 311:55 - 63Nishihara S, Tsuda L, Ogura T (2003) The canonical WNT pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem Biophys Res Comm 311 :55-...
Interpretation: In conclusion, the aberrant reactivation of the canonical WNT pathway in the adult airway epi-thelium recapitulates the diseased phenotype observed in COPD patients, suggesting that this pathway or its downstream effectors could represent a future therapeutic target....
The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervoussystem development. Given its various functions, dysfunction of the canonical Wnt pathway may exert adverse effects on neurodevelopment and therefore leads to the pathogenesis of autism. Here...
Canonical Wnt pathway inhibitor ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent manner. Grigson ER,Ozerova M,Pisklakova A,et al. PLoS One . 2015Grigson ER, Ozerova M, Pisklakova A, Liu H, Sullivan DM, Nefedova Y. Canonical Wnt pathway inhibitor ICG-001 induces ...
多项研究结果显示β-连环素是Wnt信号转导通路的关键调控点并是构成粘附连接的E-cd/cat复合体的胞内重要组份,并通过与多种蛋白的结合参与肿瘤的发生发展、增殖分化、侵袭转移等生物学过程。 3. Wnt signaling pathway is initiated by the secreted Wnts pro -teins. Wnt信号转导通路,即由Wnt基因编码产物所介...
PNAS Plus: Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins PNAS Plus: Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteinsmacropinocytosis, arginine methylation, ESCRT, ... N Tejeda-Muoz,LV Albrecht,MH Bui,.....
经典Wnt信号途径1. Methylation status of canonical Wnt signaling pathway-related genes in lung carcinoma and adjacent normal tissues; 肺癌及癌旁组织中经典Wnt信号途径相关基因的甲基化状态观察2) noncanonical Wnt signal pathway 非经典的Wnt信号途径 1. According to the different modes of Wnt protein-...
elegans also has a canonical Wnt pathway that converts POP-1 into an activator and controls the expression of several homeobox genes. Interestingly, these different Wnt pathways use distinct beta-catenins...
Lung development is a consequence of interaction between epithelium and mesenchyme,which is regulated by several signaling pathways.It is well known that the canonical WNT signal pathway plays an important role in the regulation of cell proliferation,apoptosis and differentiation.Recent studies on model ...
After 8 hours of oscillatory flow, HAECs infected with lentivirus of Wnt reporter demonstrated markedly increased luciferase activity compared to cells under static condition, suggesting an activation of canonical Wnt signaling pathway with OSS. We further demonstrated that Wnt3a, a Wnt activator, up...