In contrast, Wnt16 activates non-canonical Wnt signaling in osteoclast precursor cells and suppresses the Rankl-induced activation of Nf-魏b and Nfatc1, thereby inhibiting osteoclast differentiation. Conclusion Wnt5a and Wnt16 tightly regulate osteoclast differentiation and function in order to maintain ...
To test whether non-canonical Wnt signaling is required for ISC migration, we knocked down components of the pathway in ISCs, before infecting flies withEcc15. Infection-induced cellular protrusions, as well as ISC migration, were no longer observed after depleting Dsh, Otk, or the secondDrosoph...
Interestingly, these different Wnt pathways use distinct beta-catenins to control POP-1 function: the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated ...
WNT5A, a non-canonical WNT ligand, has been shown to promote adipose tissue inflammation and insulin resistance in animal studies. Among other non-canonical pathways, WNT5A activates planar cell polarity (PCP) signaling. The current study investigated the potential contribution of non-canonical WNT...
Wnt signaling through canonical and non-canonical pathways: Recent progress The Wntbeta-catenin pathway regulates cell adhesion, morphology, proliferation, migration and structural remodeling. The aspects of the canonical and non-c... Widelitz,Randall - 《Growth Factors》 被引量: 465发表: 2005年 ...
However, the mechanisms of action of the non-canonical Wnt signaling pathway in CRC are not yet completely understood.9 In mammals, 19 types of Wnt proteins have been described.9 Some Wnt proteins such as Wnt-3 and Wnt-1 can activate both the canonical pathway and the non-canonical pathway...
Wnt signaling is widely recognized as essential for normal and cancer stem cell. Moreover, β-catenin-dependent Wnt pathway, referred to as canonical, has gained attention, while β-catenin-independent Wnt pathways, known as non-canonical, have remained conspicuously less explored. However, recent ...
It is interesting to speculate about an interrelationship between the Wnt signalling pathways as a potential pathological mechanism in chronic metabolic diseases. The aim of this review is to summarize reported findings on the contrasting roles of Wnt signalling in lifestyle-related chronic metabolic ...
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory. Here, we identified Mcam, a potential member of t
Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases.doi:10.1177/1479164117738442Wnt signalling... Ian,Ackers,Ramiro,... - 《Diabetes & Vascular Disease Research》 被引量: 0发表: 2017年 Three 4-letter words of hypertension-related cardiac hypertrophy:...