The scope of non-coding RNA includes, but is not limited to, the following subjects: -Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway, small nuclear...
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of cancers, as well as many other diseases. Over the past decade, substantial effort has been made towards the clinical application ...
Non-coding RNA Researchaims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease … ...
A. Decrypting noncoding RNA interactions, structures, and functional networks. Genome Res. 29, 1377–1388 (2019). CAS PubMed PubMed Central Google Scholar Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity...
Targeting tRNA-Derived Non-Coding RNA Alleviates Diabetes-Induced Visual Impairment through Protecting Retinal Neurovascular Unitdoi:10.1002/advs.202411042diabetic retinopathyneuropathyneurovascular dysfunctiontRNA‐derived stress‐induced RNAsvasculopathyDiabetes is a major risk factor for compromised visual health,...
Studies have found that RNA encoding proteins only account for a small part of the total number, most RNA is non-coding RNA, and non-coding RNA may affect
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Long noncoding RNAs snRNAs: Small nuclear RNAs mRNAs: Messenger RNAs LCSCs: Liver cancer stem cells USP22: Ubiquitin-specific protease 22 HIF-1α: Hypoxia-inducible factor-1α CAFs: Cancer-associated fibroblasts HGF: Hepatocyte growth factor ceRNA: Competing endogenous RNA TAMs: Tumor...
RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or employing RNA molecules for therapeutic purposes. Amongst the most promising targets are long non-coding RNAs (lncRNAs), which regulate oncogenic molecular networks in a cell type-restricted manner. lncRNAs are distinct...
(primarily as ceRNAs).7miRNAs mostly regulate gene expression at the posttranscriptional level through RNA interference by binding to the 3′-untranslated region (3′UTR) (rarely 5′UTR or coding sequence) of protein-coding mRNAs.8,9,10In addition, some TRFs and tiRNAs can participate in ...