Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy. 2008;4:1083-1085.Scarlatti F, Maffei R, Beau I, Ghidoni R, Codogno P. Non-canonical autophagy: an exception or an underestimated form of autophagy? Autophagy. 2008;4:1083-5....
Non-canonical autophagy is therefore not blocked by the knockdown of Beclin I or of its binding partner hVps34. Moreover overexpression of Bcl-2, which is known to block canonical starvation-induced autophagy by binding to Beclin 1, is unable to reverse the non-canonical autophagy triggered ...
Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev Mol Cell Biol . 2011; 13 : 7–12. doi: 10.1038/nrm3249Codogno P, Mehrpour M, Proikas-Cezanne T. Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev ...
Figure 1. Pharmacological activation of non-canonical autophagy promotes ATG8-PS lipidation in cells (A) Confocal images of WT and ATG13−/− MCF10A cells upon activation of canonical (PP242/BafA1) and non-canonical autophagy (monensin). Scale bar: 20 μm. (B) Coomassie staining of GFP...
RACK1 depletion induces non-canonical autophagy Autophagy has a very complicated mechanism and a lot of factors that contribute to its flux in diverse ways. Pointing out a few examples, ULK1, Atg13 and RB1CC1 are major components of the Ulk1 complex, which is involved in the initiation step...
Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,...
reveal that distinct autophagy programs are used by different cells within an animal, and disclose an unappreciated role for ubiquitin activation in autophagy... Chang,Tsun-Kai,Shravage,... - 《Nature Cell Biology》 被引量: 101发表: 2013年 Vaccine activation of the nutrient sensor GCN2 in den...
Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy 来自 Semantic Scholar 喜欢 0 阅读量: 34 作者:R Shiloh,Y Gilad,Y Ber,M Eisenstein,D Aweida,S Bialik,S Cohen,A Kimchi 摘要: Autophagy is an intracellular degradation process essential for ...
Rapid dissociation between Ulk1 and AMPK primes cells for fast autophagy induction upon nutrient ... L Shang,C She,F Du,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 510发表: 2011年 Simultaneous Induction of Non-Canonical Autophagy and ...
it was originally described thatthese peptides can also originate from macroautophagy substrates. In recent years it hasbecome clear that in addition to this canonical function of the macroautophagy machineryduring MHC class II restricted antigen presentation at least parts of this machinery are alsous...