NOD-like Receptor Signaling PathwayOverview Diagram Introduction The innate immune system is the first line of defense against microbial invasion, relying on pattern recognition receptors to recognize external pathogenic microorganisms and then remove them. Toll-like receptors (TLRs) and Nod-like receptors...
This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.Zhou, Yujie...
TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions Toll-Like Receptor Signaling Pathways Type I Interferon Signaling Pathways Type II Interferon Signaling Pathways Type III Interferon Signaling Pathways VEGF - VEGF R2 Signaling Pathways ...
NOD-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recogniti...
Overall, transcriptional alterations may contribute to the physiological responses in zebrafish under BaP exposure. Extracellular BaP could trigger the up-regulation of gene expression NOD-like receptor signaling pathway. An enhanced expression of these genes leads to an increase in cytokines IL-1β and...
our approach provided more information about the transcriptional dysregulation in the epidermis. A good example is the recognition of the NOD-like receptor signaling and functions related to it, such as inflammasome activation in keratinocytes. The 5′-end RNAseq method allowed the precise determination...
Background Currently, it is well established that cancer arises in chronically inflamed tissue. A number of NOD-like receptors (NLRs) form inflammasomes, intracellular multiprotein complexes critical for generating mature pro-inflammatory cytokines (IL-1
Ubiquitin specific protease 21 upregulation in breast cancer promotes cell tumorigenic capability and is associated with the NOD-like receptor signaling pathway... L Peng,Y Hu,D Chen,... - 《Oncology Letters》 被引量: 0发表: 2016年 Tumor growth-promoting properties of macrophage migration inhibit...
8. Zamboni D. et al., 2006. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol. 7(3):318-25. 9. Zhao Y. et al., 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion ...
(NLRs;nucleotide-bindingdomainleucine-richrepeat containingreceptors)detectmicrobialcomponentsinthecytosol. TheintracellularNLRproteinsorganizesignalingcomplexessuchasinflammasomesandNODsignalosomes.Theseproteins havebeenfirstidentifiedduetotheirhomologywiththeplantRproteins,alargefamilyofproteinsinvolvedinresistancetophyto- ...