is of vital importance to innate immunity. NOD-like receptor is activated, it wil induce the release of plenty of inflammatory factors through a variety of signaling pathways. This review presents the constitution of NOD-l...
[Key words] Nucleotide-binding oligomerization domain-like receptor; Signaling pathway; Tumor 先天性免疫应答是机体抗感染免疫的第 一道防线,相对于适应性免疫应答来说具有 出现早,应答发生速度快等特点.其主要识 别病原体相关分子模式(pathogen-associated molecular patterns,PAMPs)和损伤相关的分 子模式(damage-...
其通过模式识别受体（p a t t e r n recognition receptors，PRR）［1］来非特异地识别各种致病物质，PRR主要有以下两类受体：一类是位于细胞膜表面或内体膜上的Toll样受体（Toll-like receptor，TLR），另一类是位于细胞质内的核苷酸结合寡聚化结构域（nucleotide- binding oligomerization domain，NOD）样受体及 ...
Get Print Copy of this Pathway View NOD-like Receptor Signaling Pathways Image Related Information NLRP10 Is Required for Dendritic Cell-mediated Initiation of the Adaptive Immune Response NOD-like Receptors and the Inflammasome Obesity-Induced Activation of the Nlrp3 Inflammasome Promotes Insulin Resistan...
慢性炎症可导致HS/PC功能障碍和免疫细胞分化异常,血液系统恶性肿瘤通常存在炎症细胞因子水平增高,而NLRP3炎症小体在其中发挥重要作用。细胞焦亡是否存在于除MDS外的血液系统恶性肿瘤,如白血病发病中目前尚存争议,但是细胞焦亡过程中的NLRP3炎症小体与白血病等血液系统恶性肿瘤关系密切。NLRP3炎症小体究竟如何参与白血病的...
An overview of the NOD-like receptor signaling pathway, introduction, the regulation of pathway and clinical significance.
先天免疫系统由几种模式识别受体组成,包括 Toll 样受体(Toll-like receptors,TLRs),NOD 样受体 (NOD-like receptors,NLRs)和 RIG-1 样受体(RIG-1 like receptors,RLRs).TLRs 在细胞表面和核内体识 别细菌,而 NLRs 和 RLRs 在细胞溶质中检测细菌成 分.哺乳动物 TLRs 可以感受细胞表面及核体中由 细菌引起和...
NOD-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recogniti...
Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptorsNOD-like receptorsEstrogen receptorsColon cancerWnt/β-catenin pathwayIt has been reported that estrogen receptors (ERs) participate in carcinogenesis by directly regulating NOD-like ...
(NOD-like receptors ,NLRs )和 RIG-1 样受体 (RIG-1 与获得性免疫系统相 比,先天免疫不需要基 因重组 , like receptors ,RLRs )。TLRs 在细胞表面和核 内体识 它 的多样性依赖于若干先天免疫基 因,它们 的接合 别细菌 ,而 NLRs 和 RLRs 在细胞溶质 中检测细菌成 变异型编码在宿主基 因组 中[1] ...