leading to production of inflammatory mediators. The NLR signaling is also linked to apoptosis and inflammasome activation. The latter regulates CASP1; required for the maturation of
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggest that genes related to immune response were significantly dysregulated. Furthermore, the nucleotide-binding, oligomerization domain (NOD)-like receptor signaling pathway was significantly enriched and most of the genes...
In addition, PRRs can also initiate more complex signaling pathways to trigger immune responses such as cell apoptosis and macrophage activation (Liao and Su, 2021). Previous research has revealed that in Salmo salar, Toll-like receptors (TLRs) have been found to mediate the NF-κB signaling pa...
We further verified that GO exposure suppressed the expression of genes involved in anti-virus responses possibly through the inhibition of genes involved in NOD-like receptor signaling pathway. Furthermore, NOD-like receptor-regulated lipid genes were also inhibited, which may consequently lead to ...
Overall, transcriptional alterations may contribute to the physiological responses in zebrafish under BaP exposure. Extracellular BaP could trigger the up-regulation of gene expression NOD-like receptor signaling pathway. An enhanced expression of these genes leads to an increase in cytokines IL-1β and...
For host transcriptome KEGG analysis showed, the NOD-like receptor signaling pathway (NLRs) and TOLL-like receptor signaling pathway (TLRs) were upreguoation in HN016 infected fish than the control fish; But for proteome KEGG, only the NLRS was up, the TLRS was not change. Compared with YM...
and the “Toll-like receptor signaling pathway”. We also performed qRT-PCR to examine the expression profile of inflammation-related genes, which further verified the reliability of our transcriptome data. Based on the above results, it was concluded that the NOD/Toll-like receptor-related network...