leading to production of inflammatory mediators. The NLR signaling is also linked to apoptosis and inflammasome activation. The latter regulates CASP1; required for the maturation of
Results: The results showed that the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) signaling pathway that was involved in immunity may play a crucial function in lung injury caused by plateau hypoxia. And the expressions of NOD1, NOD2, IL-1β, TNF-α, IL-6, and IL-...
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggest that genes related to immune response were significantly dysregulated. Furthermore, the nucleotide-binding, oligomerization domain (NOD)-like receptor signaling pathway was significantly enriched and most of the genes...
For host transcriptome KEGG analysis showed, the NOD-like receptor signaling pathway (NLRs) and TOLL-like receptor signaling pathway (TLRs) were upreguoation in HN016 infected fish than the control fish; But for proteome KEGG, only the NLRS was up, the TLRS was not change. Compared with YM...
We further verified that GO exposure suppressed the expression of genes involved in anti-virus responses possibly through the inhibition of genes involved in NOD-like receptor signaling pathway. Furthermore, NOD-like receptor-regulated lipid genes were also inhibited, which may consequently lead to ...
Among the many enriched signaling pathways, the NOD-like receptor signaling pathway involved in immunity was significantly upregulated, which suggested that the NOD-like receptor signaling pathway may play a crucial function in lung in- jury caused by plateau hypoxia. The KEGG enrichment map plots ...
These DEGs were enriched into 151 KEGG pathways including a core set of immune correlated pathways notably in phagosome and NOD-like receptor signaling. DUG displayed an obvious downregulation in these immune pathways. The expression patterns of six DEGs were confirmed by RT-qPCR, and the ...
These DEGs were enriched into 151 KEGG pathways including a core set of immune correlated pathways notably in phagosome and NOD-like receptor signaling. DUG displayed an obvious downregulation in these immune pathways. The expression patterns of six DEGs were confirmed by RT-qPCR, and the ...
The KEGG pathway enrichment analysis indicated that the “MEyellow” gene module was enriched in the NOD-like receptor signaling pathway (Figure 3C). The GSE195434 dataset included samples from multiple couples in whom one partner was infected with HIV-1 while the other was healthy. By recording...
In our study, the “NOD-like receptor signaling pathway” and the “Toll-like receptor signaling pathway” served as the main pathways for KEGG enrichment, which may be the main way for the host recognition of Elizabethkingia miricola and the induction of the inflammatory response. According to...