leading to production of inflammatory mediators. The NLR signaling is also linked to apoptosis and inflammasome activation. The latter regulates CASP1; required for the maturation of
NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish - ScienceDirectYongzhan Mai aSongyao Peng aHaiyan Li aYuan Gao aZini Lai a b cComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology...
In addition, PRRs can also initiate more complex signaling pathways to trigger immune responses such as cell apoptosis and macrophage activation (Liao and Su, 2021). Previous research has revealed that in Salmo salar, Toll-like receptors (TLRs) have been found to mediate the NF-κB signaling pa...
Gene selection. Genes involved in the NOD receptor pathway were extracted by interrogating the KEGG Pathway database47. The pathway (KEGG ID: hsa04621) is composed of 56 genes, of which 41 are intrinsic to NOD signaling. Gene names were cross-referenced with the HUGO webserver to confirm...
Furthermore, NOD-like receptor-regulated lipid genes were also inhibited, which may consequently lead to decreased lipid staining in fish muscles. We concluded that 6 month-exposure to GO suppressed NOD-like receptor-regulated anti-virus signaling pathways in zebrafish....
1) involving an initial whole-genome screen for regulators of NOD2-to-NF-κB, and a subsequent filtering screen with the obtained hits on the unrelated Toll-like receptor 3 (TLR3) (unrelated endosomal/intracellular PRR)-mediated NF-κB activation, to exclude generic NF-κB regulators. The ...
For host transcriptome KEGG analysis showed, the NOD-like receptor signaling pathway (NLRs) and TOLL-like receptor signaling pathway (TLRs) were upreguoation in HN016 infected fish than the control fish; But for proteome KEGG, only the NLRS was up, the TLRS was not change. Compared with YM...
Overall, transcriptional alterations may contribute to the physiological responses in zebrafish under BaP exposure. Extracellular BaP could trigger the up-regulation of gene expression NOD-like receptor signaling pathway. An enhanced expression of these genes leads to an increase in cytokines IL-1β and...
brain samples from diseased and healthy bullfrogs were used for the RNA-Seq analysis. The comparative transcriptome analysis revealed that the diseased bullfrog brain was characterized by the immune activation and inflammatory response, which were mediated by the “NOD-like receptor signaling pathway” ...
viaSirt1/AMPKandNF-κBsignaling pathways, but also inducesNrf2activation and increasesHO-1expression as a liver protective agent [60]. Therefore, the mRNA expressions ofNrf2andHO-1expression should be further investigated. By contrast, alcohol is transported to the liver for reduction, where the ...