leading to production of inflammatory mediators. The NLR signaling is also linked to apoptosis and inflammasome activation. The latter regulates CASP1; required for the maturation of
Results: The results showed that the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) signaling pathway that was involved in immunity may play a crucial function in lung injury caused by plateau hypoxia. And the expressions of NOD1, NOD2, IL-1β, TNF-α, IL-6, and IL-...
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggest that genes related to immune response were significantly dysregulated. Furthermore, the nucleotide-binding, oligomerization domain (NOD)-like receptor signaling pathway was significantly enriched and most of the genes...
For host transcriptome KEGG analysis showed, the NOD-like receptor signaling pathway (NLRs) and TOLL-like receptor signaling pathway (TLRs) were upreguoation in HN016 infected fish than the control fish; But for proteome KEGG, only the NLRS was up, the TLRS was not change. Compared with YM...
Gene selection. Genes involved in the NOD receptor pathway were extracted by interrogating the KEGG Pathway database47. The pathway (KEGG ID: hsa04621) is composed of 56 genes, of which 41 are intrinsic to NOD signaling. Gene names were cross-referenced with the HUGO webserver to confirm...
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci. 2021;78:1233–61. https://doi.org/10.1007/s00018-020-03656-y. 76. Zanoni I, et al. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4....
Furthermore, NOD-like receptor-regulated lipid genes were also inhibited, which may consequently lead to decreased lipid staining in fish muscles. We concluded that 6 month-exposure to GO suppressed NOD-like receptor-regulated anti-virus signaling pathways in zebrafish....
1) involving an initial whole-genome screen for regulators of NOD2-to-NF-κB, and a subsequent filtering screen with the obtained hits on the unrelated Toll-like receptor 3 (TLR3) (unrelated endosomal/intracellular PRR)-mediated NF-κB activation, to exclude generic NF-κB regulators. The ...
Eicosapentaenoic acid is an omega-3 long-chain polyunsaturated fatty acid, which can effectively regulate the body's oxidative stress level and inhibit the NF-κB signaling pathway (Nikoloff et al., 2021). As a by-product of haem catabolism, biliverdin possesses antioxidant and anti-inflammatory...
Then, we intersected gene set 1 and gene set 2 and performed a KEGG pathway enrichment analysis on each resulting gene (Figure S2B). The enrichment results indicated significant involvement in the “NOD-like receptor signaling pathway” and “Necroptosis”. Therefore, based on the bioinformatic ...