NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
MCE 站:NOD-like Receptor 品牌:MedChemExpress (MCE) 概述:核苷酸寡聚结构域 (NOD) 样受体 (NLR) 是关键的细胞质模式识别受体 (PRR),在宿主先天免疫反应和免疫稳态中发挥重要作用。人类中有 23 个 NLR 家族成员,小鼠中有至少 34 个 NLR 基因。 NLR 在许多细胞类型中表达,包括免疫细胞和上皮细胞,尽管某些...
nucleicacids,likeRNA-sensingRIG-I(retinoicacid-induciblegeneI)-likereceptors(RLRs; RLHs)orDNA-sensingAIM2,amongothers.AnothersetofintracellularsensingPRRsare theNOD-likereceptors(NLRs;nucleotide-bindingdomainleucine-richrepeatcontaining receptors),whichnotonlyrecognizePAMPsbutalsoDAMPs. PAMPs FUNGI/PROTOZOABACTER...
Table 3. Select ELISAs for Quantifying Cytokines Secreted in Response to NOD-like Receptor Activation IFN-alphaIFN-betaIL-1 betaIL-6IL-8/CXCL8TNF-alpha Table 4. Small Molecule Inflammasome Inhibitors Infllammasome Inhibitors Get Print Copy of this Pathway ...
NOD 样受体 (NLR) 是高度保守的胞质模式识别受体。NLR 在细胞内感染、有毒物质和代谢扰动方面起着关键作用。NLR 根据其 N 末端结构域的变化可分为四个亚家族: NLRA, II 类反式激活因子 (CIITA)、NLRB, 神经元凋亡抑制蛋白 (NAIP)。 参考文献 [1]. Zhong Y, et al. Functions of NOD-Like Receptors ...
NOD-like receptorsautoimmune diseasesinflammasomesinhibitorsbotanicalsAutoimmune diseases are chronic immune diseases characterized by dysregulation of immune system, which ultimately results in a disruption in self-antigen tolerance. Cumulative data show that nucleotide-binding and oligomerization domain (NOD)-...
NOD-like receptors (NLRs) are a group of pattern recognition receptors that are expressed in the cell cytosol. They can sense molecules that are associated with infection (for example, bacterial peptidoglycans) and induce inflammatory immune responses that help clear the infection. ...
内容提示: International Edition 1-Nov-2009Product FlyerNOD-LIKE RECEPTORS (NLRs)IntroductionNLR ProteinsIn mammals, germ-line encoded pattern recognition receptors (PRRs) detect the presence of pathogens either directly through rec-ognition of pathogen-associated molecular patterns (PAMPs) or indirectly ...
近日,福建医科大学郑春福教授在International Journal of Biological Macromolecules(IJBM)在线发表了题为:The emerging roles of NOD-like receptors in antiviral innate immune signaling pathways的综述论文。 NOD样受体(NOD-like receptors, NLRs)是宿主的一类模式识别受体,可识别病毒的病原相关分子模式。众所周知,NLRs调...
Introduction NOD-like receptors (NLRs) protein inflammatory bodies are novel pattern-recognition receptors (PRRs). They form pattern recognition of innate immunity withtoll-like receptors(TLRs), retinoic acid-inducible gene (RIG-I) receptors (RLRs), and C-type lectin receptors(CLRs). NOD-like rece...