Furthermore, zebrafish NLRC3-like 1 interacted with the adaptor protein RIPK2 of NODs signaling via the FISNA (Fish-specific NACHT associated domain) and NACHT domains. However, the interaction between zebrafish NLRC3-like 1 and RIPK2 inhibited the assembly of the NOD1-RIPK2 complex. Importantly,...
TheinnateimmunesensorNLRC3attenuatesToll-likereceptor signalingviamodificationofthesignalingadaptorTRAF6and transcriptionfactorNF-κB MonikaSchneider 1 ,AlbertGZimmermann 2 ,ReidARoberts 1 ,LuZhang 3 ,KarenV Swanson 2 ,HaitaoWen 2 ,BeckleyKDavis 2,6 ,IrvingCAllen 2 ,EdaKHoll 1,6 ,Zhengmao Ye 1,6...
Here we report the identification and characterization of a mutant zebrafish, which harbors a point mutation in the nucleotide-binding oligomerization domain (NOD) like receptor gene nlrc3-like, resulting in the loss of microglia in a temperature sensitive manner. Temperature shift assay reveals that...
Furthermore, piscine NLRC3-like genes were confirmed to have a negative or positive regulatory function in response to different kinds of pathogen infections and in the production of proinflammatory cytokines. In this review, we summarize recent advances in our understanding of the expanding and ...
Our results indicate that heat stress suppressed the immune response level via the NLRC3-like protein, the fine-tuning of protein turnover activity, and ATP metabolism. This might disrupt the balance of coral-zooxanthellae symbiosis and result in the bleaching of the coral A. aculeus. (C) ...
Characterization and functional assessment of the NLRC3-like molecule of the goldfish ( Carassius auratus L.)MacrophagesFishNLRNLRC3LASCRIP2Gene expression
NLRC3Atlantic salmonThe nucleotide binding oligomerization domain like receptors, or NOD like receptors (NLRs), are intracellular receptors responsible for recognizing pathogens in vertebrates. Several NLR mammalian models have been characterized and analyzed but few studies have been performed with teleost ...
Characterization and expression profiling of NOD-like receptor C3 (NLRC3) in mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge. Fish Shellfish Immunol. 2017, 66, 231-239. [CrossRef] [PubMed]Z.M. Hou, Z. Ye, D.D. Zhang, C.B. Gao, B.F. Su, L. ...
Nod like receptorsNLRsNLRC3PRRAsian seabassLates calcariferBacterial infectionPoly I:CGene expression•A novel NLRC3 transcript was cloned and characterised from Asian seabass,Lates calcarifer(AsNLRC3).•AsNLRC3 is different from the NLR subfamily C of other teleosts.•Ontogenic expression ...