Here we report the identification and characterization of a mutant zebrafish, which harbors a point mutation in the nucleotide-binding oligomerization domain (NOD) like receptor gene nlrc3-like, resulting in the loss of microglia in a temperature sensitive manner. Temperature shift assay reveals that...
The NLRC3-like (NLRC3L) molecule from the goldfish transcriptome database was identified and characterized. Quantitative gene expression analysis revealed the highest mRNA levels of NLRC3L were in the spleen and intestine, with lower mRNA levels observed in muscle and liver. Goldfish NLRC3L was ...
Suppression of NF-kappa B signal pathway by NLRC3-like protein in stony coral Acropora aculeus under heat stressHeat stress - 《Fish & Shellfish Immunology》 被引量: 0发表: 2017年 The Percentage of Coverage of Living Coral Reef Type and Composition in Malelaya Village of Punaga Town in Man...
TheinnateimmunesensorNLRC3attenuatesToll-likereceptor signalingviamodificationofthesignalingadaptorTRAF6and transcriptionfactorNF-κB MonikaSchneider 1 ,AlbertGZimmermann 2 ,ReidARoberts 1 ,LuZhang 3 ,KarenV Swanson 2 ,HaitaoWen 2 ,BeckleyKDavis 2,6 ,IrvingCAllen 2 ,EdaKHoll 1,6 ,Zhengmao Ye 1,6...
Human NOD-like receptor family CARD domain containing 3 (NLRC3) ELISA Kit (RK11680) suitable for serum, plasma, cell culture supernatants and urine in . 100% guaranteed. ABclonal provide all the time-savings, convenience and performance of a high-end, co
Furthermore, zebrafish NLRC3-like 1 interacted with the adaptor protein RIPK2 of NODs signaling via the FISNA (Fish-specific NACHT associated domain) and NACHT domains. However, the interaction between zebrafish NLRC3-like 1 and RIPK2 inhibited the assembly of the NOD1-RIPK2 complex. Importantly,...
Our results indicate that heat stress suppressed the immune response level via the NLRC3-like protein, the fine-tuning of protein turnover activity, and ATP metabolism. This might disrupt the balance of coral-zooxanthellae symbiosis and result in the bleaching of the coral A. aculeus. (C) ...
Furthermore, piscine NLRC3-like genes were confirmed to have a negative or positive regulatory function in response to different kinds of pathogen infections and in the production of proinflammatory cytokines. In this review, we summarize recent advances in our understanding of the expanding and ...
Characterization and functional assessment of the NLRC3-like molecule of the goldfish ( Carassius auratus L.)MacrophagesFishNLRNLRC3LASCRIP2Gene expression
NLRC3Atlantic salmonThe nucleotide binding oligomerization domain like receptors, or NOD like receptors (NLRs), are intracellular receptors responsible for recognizing pathogens in vertebrates. Several NLR mammalian models have been characterized and analyzed but few studies have been performed with teleost ...