(Shiojima et al., 1995). It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tin...
It has been demonstrated that a Drosophila homeobox-containing gene called 'tinman' is expressed in the developing dorsal vessel and in the equivalent of the vertebrate heart. Mutations in tinman result in loss of heart formation in the embryo, suggesting that tinman is essential for Drosophila ...
We have found that Nkx2-5 positively and directly regulates a novel target gene, Ccdc117, in cells of the SHF at these stages. The nuclear/mitotic spindle associated protein Ccdc117 interacts with the MIP18/MMS19 cytoplasmic iron-sulfur (FeS) cluster assembly (CIA) complex, which transfers ...
背景资料 Homeobox protein Nkx-2.5,also known as NKX2E or CSX is a protein that in humans is encoded by the NKX2-5 gene.It is mapped to 5q35.1.Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation,as well as determining...
AssociationofNKX2—5genewithcongenitalheartdisease L儿 Xing—yuan’。YANGYi—qing. YANGYing,LINXiao—ping,CHENYi—han. 1.DepartmentofPaediatrics,TongJi UniversityAffiliatedTongJiHospital,Shanghai 200065,China;2.DepartmentofCardiolo— gY,TongjiUniversityAffiliatedTongjiHospitalandtheInstituteofMedicalGeneticsAffili...
CDS-M06244-1 pDonR223-NKX2-5 GateWay 2ug/0.5ml ￥0 现货 CDS-M06244-2 pMD18-T-NKX2-5 TA克隆 2ug/0.5ml ￥0 1-2周NKX2-5 重组病毒 货号产品名称Method规格价格货期 CDS-M06244-11 rAd-NKX2-5 重组腺病毒 10^10cfu/支 ￥3000 3-5周 CDS-M06244-12 rAAV-NKX2-5 重组腺相关病毒 10...
Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. Here, we show deletion of NKX2-5, a critical component of the cardiac gene regulatory network, in human embryonic stem cells (hESCs), results in impaired c
NKX2-5( AAH25711, 1 a.a. - 325 a.a.) full-length recombinant protein with GST.,货号:H00001482-P01抗体http://www.abnova.com.tw/product_search/PS_detail_protein.asp?catalog_id=H00001482-P01&geneid=1482
The cardiac transcription factor (TF) genehas been associated with electrocardiographic (EKG) traits through genome-wide association studies (GWASs), but the extent to which differential binding of NKX2-5 at common regulatory variants contributes to these traits has not yet been studied. We ...
Numerous mutations in NKX2-5 gene have been reported in CHD patients, including atrial septal defect, ventricular septal defect (VSD) and tetrology of Fallot. We have previously identified the sequence variants within the NKX2-5 gene promoter in VSD patients. As several studies have revealed ...