The mechanisms involved in the expression of the ligands of NKG2D play a key role in the recognition of stressed cells by the immune system and represent a promising therapeutic target for improving the immune response against cancer or autoimmune disease. In this review, we analyse the recent ...
585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and...
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and limited treatment options. Chimeric antigen receptor (CAR)-T cell therapy holds promise, but its efficacy is hindered by tumor antigen escape and heterogeneity. To address these challenges, we developed a novel bi...
The secreted BiTEs could promote the cytotoxicity of untransduced T cells against NKG2DL + tumor cells. In vitro, BiTEs CAR-T cells exhibited superior cytotoxicity, T cell activation, and cytokines production against heterogeneous target cells compared to MSLN CAR-T. In vivo, BiTEs CAR-T ...
Therefore, while NKG2D may provide beneficial in surveillance against cancer and infections, there is emerging evidence that this system may have a detrimental role in some autoimmune disorders. Our findings that NKG2D blockade is an efficient therapy for type I diabetes suggests a new strategy for ...
(NKG2D-L) loss mutants provides a mechanism of tumor escape.7 Tumor cells develop mechanisms to escape from innate immune surveillance and these strategies include shedding of NKD2D-Ls from target cells to inhibit NK cell activity as demonstrated in many studies for different tumor entities.8 ...
Methods for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising an NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. The methods disclosed herein are useful for the treatment of cancer that is associated...
ThisreviewsummarizesrecentfindingsconcerningtheroleofNKG2Dreceptor–ligandsystemincancer withemphasisonregulationofNKG2Dligandexpressionandtheimmunosuppressiveroleofexosomally expressedNKG2Dligands. ©2014ElsevierLtd.Allrightsreserved. 1.Introduction 1.1.Exosomes–vehiclesforintercellularcommunicationin ...
Mini review NKG2D and its ligands NK cellrecognition of target cells. (a) Normal target cells express self-MHC class I molecules in sufficient quantities to engage inhibitoryNK cell receptors. The cells may also express low levels of activating ligands, but provided that they are not ligands for...