参考文献: Liu H, Wang S, Xin J, Wang J, Yao C, Zhang Z. Role of NKG2D and its ligands in cancer immunotherapy. Am J Cancer Res. 2019 Oct 1;9(10):2064-2078. PMID: 31720075; PMCID: PMC6834480. Fuertes MB, Domaica CI, Zwirner NW. Leveraging NKG2D Ligands in Immuno-Oncology. Fro...
NKG2D产生的信号可直接激活NK细胞发挥杀伤效应,并作为协同刺激信号促进αβT细胞和γδT细胞的活化并增强其杀伤效应。Figure 3. The interaction between NKG2D and its ligands*This diagram is derived from reference 1.自1997年全球首款抗CD20单抗——罗氏的利妥昔单抗获批以来,全球已经批准多款抗CD20单抗。根据人...
[2] Lanier, Lewis L. "NKG2D receptor and its ligands in host defense." cancer immunology research 3.6 (2015): 575-582.[3] Jones, Amber B., et al. "Regulation of NKG2D stress ligands and its relevance in cancer progression." Cancers 14.9 (2022): 2339.[4] Baumeister, Susanne H.,...
[2] Lanier, Lewis L. "NKG2D receptor and its ligands in host defense." cancer immunology research 3.6 (2015): 575-582. [3] Jones, Amber B.,et al."Regulation of NKG2D stress ligands and its relevance in cancer progression." Cancers 14.9 (2022): 2339. [4] Baumeister, Susanne H.,et ...
NKG2D and its ligands can also be regarded as a kind of tumor marker, serving as a crucial prognostic factor and indicator in the formulation of treatment protocols. Meanwhile, tumor cells can down-regulate the expression of NKG2G/NKG2DL by means of varied humoral or cellular immunity pathways...
Role of NKG2D and its ligands in cancer immunotherapy[ J]. Am J Cancer Res, 2019, 9(10): 2064-2078. 14. Yue H, Sun F, Zhang X, et al. CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy[ J]. J Cancer Res Clin Oncol...
NKG2D and its ligands 来自 Semantic Scholar 喜欢 0 阅读量: 25 作者: P Obeidy,AF Sharland 展开 摘要: NKG2D is an activating immunoreceptor, first recognized on NK cells but subsequently found on gammadelta T cells, CD8(+) alphabeta T cells and macrophages. In NK cells, inhibitory ...
defined as transformation, infection or cell stress. This review summarizes recent findings that concern NKG2D, its ligands, its signalling properties and its role in disease, and provides a framework for considering how the induction of immune responses can be regulated by cellular responses to injur...
anditsligandsplayanimportantroleintheNK,6andCD8T—cell—mediatedimmuneresponsetotumors.EngagementofNKG2DligandsontumorcellsbyNKG2Dtriggersefectorcellstoeliminatetumorcells.However,tumorsexpressingNKG2Dligandscandevelopinfullyimmune—competentanimals.Therefore,theremustexistimmuneescapemechanismsintumormiceandcancerpatients...
NKG2D is a costimulatory receptor expressed on activated NK cells and certain groups of T cells, and there is evidence that it might carry out surveillance against cancer and infections. The ligands of NKG2D, including RAE-1, are known to be molecules whose expression is triggered by oncological...