These cells are hyporesponsive to T cell receptor (TCR)–mediated signaling but, like NK cells, can mount robust CD16-mediated cytotoxic responses. These CD8+ γδ T cells comprise a highly focused TCR repertoire, with clonotypes that are Mycobacterium specific but not phos...
Cytokine-induced killer (CIK) cells are a unique population of cytotoxic T lymphocytes (CTL) with the characteristic CD3+CD56+ phenotype. These cells have demonstrated higher proliferative and cytolytic activities in comparison to the reported CD3CD56+ lymphokine activated killer (LAK) cells that are...
Cytokine-induced NK-like T cells: from bench to bedside. J Biomed Biotechnol 2010;1-8 (Article ID 435745). Following cell expansion, activation occurs,... Kam,M,Hui - 《Expert Opinion on Biological Therapy》 被引量: 32发表: 2012年 Bench-to-bedside review: Natural killer cells in sepsis...
A higher proportion of NK-like T-cells (of total lymphoid cells) was found in MDS compared to controls (P=0.01). A lower proportion of NK-like T-cells predicted better survival in AML but not in MDS. Thus, the proportions of NK, NK-cell subsets, and NK-like T-cells vary in ...
blood picture: a significant increase in the number of NK cells with a CD3 + CD16 + CD56 + phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3 + CD16 + CD56 + phenotype; a significant decrease in the number and percentage of T CD3 + cells. ...
While NK cells were the dominant cell type in the lymphocyte compartment until day + 14, CD8+ T cells reconstituted and replaced the NK cells as the dominant lymphocyte type by day + 28 (Fig. 3A). We evaluated the immunophenotype of the NK cells in the peripheral blood over time...
A higher proportion of NK-like T-cells (of total lymphoid cells) was found in MDS compared to controls (P=0.01). A lower proportion of NK-like T-cells predicted better survival in AML but not in MDS. Thus, the proportions of NK, NK-cell subsets, and NK-like T-cells vary in ...
Human cytomegalovirus (HCMV) profoundly impacts host T and NK cells across the lifespan, yet how this common congenital infection modulates developing fetal immune cell compartments remains underexplored. Using cord blood from neonates with and without congenital HCMV (cCMV) infection, we identify an...
the following changes in the blood picture: a significant increase in the number of NK cells with a CD3CD16CD56 phenotype; a proportional increase in the number and percentage of NKT-like cells with a CD3CD16CD56 phenotype; a significant decrease in the number and percentage of T CD3 cells...
which resulted in the diminished long-term effects. The focus of this review is to discuss about the activity of NK cells and cells with NK-like activity including natural killer T (NKT), cytokine-induced killer (CIK) and lymphokine-activated killer (LAK) cells in immunotherapy of human sol...