2023年1月,哈佛医学院附属麻省总医院肿瘤研究中心的研究人员在Frontiers in Immunology(免疫学前沿)上发文“Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells”,阐明NK细胞可以消除循环肿瘤细胞(circul...
Reference: Journal of Immunology. "Killer cell immunoglobulin-like receptors: function and signaling in natural killer cells." (Year and specific issue will depend on the latest research, but you can find the most relevant article in the journal's archive.)Reference: Nature Reviews Immunology. "T...
细胞因子诱导记忆样NK细胞 除了细胞因子直接参与NK细胞的分化和功能外,炎症性细胞因子(IL-12, IL-15 和 IL-18)还可以在缺乏抗原的情况下赋予小鼠和人类NK细胞记忆样特征,称为细胞因子诱导的记忆样(cytokine-induced memory-like,CIML)NK细胞,这种现象2009年被哈佛大学休斯医学研究所的Cooper等人发现。 关键表型特征 ...
适应性NK细胞的特性包括更长的存活时间、增强的新陈代谢、抵抗来自髓源性抑制性细胞的抑制、抵抗Treg介导的抑制以及减少抑制性检查点受体的表达。近年来,有一种人工体外诱导的方法处理NK细胞,诱导成为具有类似适应性NK的细胞——记忆样NK细胞(Memory like NK cells),相关概念已经在临床当中得到了验证,疗效良好,并且有...
1.Decidual-Like NK Cell Polarization: From Cancer Killing to CancerNurturing. Cancer Discov. 2020 Dec 4. 2. Features of Human Decidual NK Cells in Healthy Pregnancy and DuringViral Infection. Front. Immunol., 28 June 2019 福利:20201218 FDA review ...
2、Natural killer cells in intracranial neoplasms: presence and therapeutic efficacy against brain tumours；Justyna Kmiecik 3、Ex Vivo Expanded and Activated Natural Killer Cells Prolong the Overall Survival of Mice with Glioblastoma-like Cell-Derived Tumors 4、Phase II trial using haploidentical ...
最为重要的是Killer Cell Immunoglobulin-like Receptors (KIRs)和NKG2D受体,它们可以识别肿瘤细胞表面的变异抗原或缺失的MHC-I分子,从而区分正常细胞和异常细胞。 ②杀伤机制:NK细胞可以通过多种方式杀伤靶细胞,包括释放穿孔蛋白质(如穿孔素)、诱导凋亡(通过释放细胞毒素如颗粒酶)和调动其他免疫细胞(如巨噬细胞)来清除...
In nonvaccinated, immunologically naive calves as young as 1 day old, a population of CD8+ cells proliferated and produced IFN-纬 in response to BCG-infected DC. CD3 CD8+ NK-like and CD3+ CD8+ T cells were evident within the responding CD8+ population. The response was not MHC-restricted...
识别机制:NK细胞通过表面上的受体来识别靶细胞。最为重要的是Killer Cell Immunoglobulin-like Receptors (KIRs)和NKG2D受体,它们可以识别肿瘤细胞表面的变异抗原或缺失的MHC-I分子,从而区分正常细胞和异常细胞。 杀伤机制:NK细胞可以通过多种方式杀伤靶细胞,包括释放穿孔蛋白质(如穿孔素)、诱导凋亡(通过释放细胞毒素如颗...
为了避免对健康组织细胞造成误伤,NK细胞通过表达KIRs (immunoglobulin(Ig)-like receptors)、CD94–NKG2和MHCI-peptide结合来负调控活性。当NK细胞识别MHC所呈递peptide为自身抗原肽时,启动抑制信号,阻止NK对自身健康细胞的杀伤(图1-a)。一旦肿瘤细胞或其他损伤的细胞为逃逸获得性免疫追杀而下调MHC消除抑制信号,NK细胞...