下一代杀手锏,NK细胞结合器! 前言:NK细胞结合器(NK Cell Engagers,NKCE)和T细胞结合(T Cell Engagers, TCE)的第一性原理是一样的。 都通过一段具有特异性识别的蛋白,把肿瘤细胞和免疫细胞拉在一起,形成免疫突触,激活免疫细胞,从而杀掉肿瘤细胞。 在进行药物设计时,相同的是肿瘤相关靶点,不同的是TCE靶向T细胞...
研究还表明，NK细胞在将树突状细胞募集到肿瘤中并提供支持其存活的生态位，从而增强CD8+T细胞反应的能力；而T细胞分泌的IL-2，可激活NK细胞抗肿瘤功能。NK细胞募集树突状细胞，从而激活T细胞反应 当前的免疫疗法，主要基于T细胞的抗肿瘤免疫，肿瘤细胞下调或MHC-1表达丧失介导T细胞免疫的耐药。T细胞和NK细胞的功能互补，...
1.Adjuvant cellular immunotherapy in patients with resected primary non-small cell lung cancer.Oncoimmunology.2015 2.Designing Cancer Immunotherapies That Engage T Cells and NK Cells.Annu Rev Immunol.2023 声明:本文仅作健康科普,不能替代医院的检查和治疗。如有相关疾病,请及时去正规医疗机构就诊,谨遵医嘱...
1.Adjuvant cellular immunotherapy in patients with resected primary non-small cell lung cancer.Oncoimmunology.2015 2.Designing Cancer Immunotherapies That Engage T Cells and NK Cells.Annu Rev Immunol.2023 声明:本文仅作健康科普,不能替代医院的检查和治疗。如有相关疾病,请及时去正规医疗机构就诊,谨遵医嘱。
1.Tarazona R, Lopez-Sejas N, Guerrero B, Hassouneh F, Valhondo I, Pera A, Sanchez-Correa B, Pastor N, Duran E, Alonso C et al: Current progress in NK cell biology and NK cell-based cancer immunotherapy. Cancer immunology, immunotherapy : CII 2020, 69(5):879-899. ...
Nivolumab plus ipilimumab in advanced non–small-cell lung cancer[J]. New England Journal of Medicine, 2019, 381(21): 2020-2031. [4].Yu X, Harden K D, Gonzalez L C, et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory ...
1.Tarazona R, Lopez-Sejas N, Guerrero B, Hassouneh F, Valhondo I, Pera A, Sanchez-Correa B, Pastor N, Duran E, Alonso C et al: Current progress in NK cell biology and NK cell-based cancer immunotherapy. Cancer immunology, immunotherapy : CII 2020, 69(5):879-899. ...
基于这个基因编码的蛋白信息,Grogan和她的同事就将这个蛋白命名为TIGIT(T cell immunoglobulin and ITIM domain,T细胞免疫球蛋白和ITIM结构域)[4]。这也就是备受关注的TIGIT名字的最初来源。 在这个研究中,Grogan团队还发现TIGIT是一个抑制T细胞活性的分子,它的高亲和力核心受体——脊髓灰质炎病毒受体(PVR),还可以称...
NK and T cell co-targeting. Similar content being viewed by others Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy ArticleOpen access01 March 2021 Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy ...
T cell and natural killer (NK) cell populations. The vaccine targets the MICA and MICB (MICA/B) stress proteins expressed by many human cancers as a result of DNA damage2. MICA/B serve as ligands for the activatin...