The field of NK cell-based cancer therapy has grown exponentially and currently constitutes a major area of immunotherapy innovation. This provides a new avenue for the treatment of cancerous lesions in the brain. In this review, we explore the mechanisms by which the brain tumor microenvironment...
alongside satisfactory product efficacy and safety. Recent developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic capacities. This review focuses on surface
国外知名杂志《Oncotargets and Therapy》公布了一例肝癌晚期应用NK(自然杀伤)细胞疗法治疗的病例报告。 2016年6月,一名患有晚期弥漫性肝细胞癌(HCC)的59岁男性,同年10至12月期间,他在全身麻醉下接受了腹膜穿刺手术和药物注射(重组人血管内皮抑制素、顺铂、洛铂);2017年3月,他接受了腹腔内灌注(重组人血管内皮抑制素...
This review explores the role of NK cells in the brain tumor microenvironment, emphasizes preclinical research with NK cells, examines effects of NK-cell-based therapies in adult and pediatric patients with brain tumors, and discusses tracking the delivery of infused NK cells through molecular neuroim...
2024年NK、CAR-NK、CAR-T、TIL、TCR-T五大细胞疗法疗效数据盘点,完全缓解率突破50%,通杀血癌及实体瘤,开启抗癌"私人定制"时代 癌症作为一种极其狡猾且复杂的疾病，它擅长伪装且会不断进化，因此，“联合疗法至关重要”，在现阶段，仅仅依靠单一的治疗手段往往难以达到预期的治疗效果。在早期精准诊断的基础之上，以...
In this review, we will discuss the dichotomy between the antitumor and antiviral functions of NK cells related to oncolytic virotherapy. We will also review NK cell-based and OV-based therapies, engineered OVs aimed at enhancing immune stimulation, and combination therapies involving OVs and NK ...
[2]Zhao X,et al.Current status and future perspective of natural killer cell therapy for cancer[J].Medical Review,2023,3(4):305-320. https://www.degruyter.com/document/doi/10.1515/mr-2023-0031/html [3]Muth J,...
其中NK细胞接合器（NK cell engagers，NKCEs）被认为是具有潜力的免疫疗法之一。NK细胞介导的癌症免疫疗法在过去二十年中得到快速发展。最近，多特异性NK细胞接合器已被成功开发成为可有效诱导内源性NK细胞针对特异性肿瘤靶标产生细胞溶解反应的癌症治疗药物。这些药物的分子的结构各不相同，但它们通常具有与特定肿瘤...
Review article: Current Perspectives on “Off-The-Shelf” Allogeneic NK and CAR-NK Cell Therapies References Abel AM, Yang C, Thakar MS, et al. Natural Killer Cells: Development, Maturation, and Clinical Utilization. Front Immunol. 2018; 9:1869. Cell th...
NKMAX's natural killer (NK) cell-based therapy, SNK01, is being tested for the effectiveness in the treatment of stroke.NKMAX said on Friday that its U.S. subsidiary, NKGen Biotech, has received Institutional Review Board (IRB) approval of Hospital Angel