2024年4月8日,来自美国加州大学洛杉矶分校的Timothy E. O’Sullivan在Nature Immunology期刊发表题为MEF2C regulates NK cell effector functions through control of lipid metabolism(MEF2C 通过控制脂质代谢调节NK细胞的效应功能)的文章。研究发现M...
2024年4月8日,来自美国加州大学洛杉矶分校的Timothy E. O’Sullivan在Nature Immunology期刊发表题为MEF2C regulates NK cell effector functions through control of lipid metabolism(MEF2C 通过控制脂质代谢调节NK细胞的效应功能)的文章。研究发现MEF2C缺乏导致NK细胞数量和功能下降,增加病毒感染风险。从机制上讲,MEF2C...
Considering the NK cell downregulation in obese individuals and the possible stimulatory-effects of macrophages, variations of NK cell functions and underlying mechanisms were investigated in mice with Apoc3-induced hyperlipidemia. Methods Variations of activities and glycolipid metabolism in NK cells of ...
将 TH2-MPP 确定为异常 T 细胞群,具有维持 2 型炎症的潜力,并支持慢性 T 细胞反应可以通过祖细胞随时间协调的证据。 4.Nat Immunol(30.5)| 2024.04.08 | MEF2C regulates NK cell effector functions through control of lipid met...
In a mouse model of B cell lymphoma, dysfunctional NK cells expressed the lipid scavenging receptors CD36 and Scavenger Receptor Class B Member 1 (Scarb1) had elevated lipid droplet content [26]. Fig. 2 Nutrient transport supports NK cell signalling and metabolism. Numerous nutrient transporters...
Natural killer (NK) cells are important early responders against viral infections. Changes in metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell dysfunction in obesity and cancer. However, very little is known a
Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol. 2005;5:844–52. Article CAS PubMed Google Scholar MacIver NJ, Michalek RD, Rathmell JC. Metabolic regulation of T lymphocytes. Annu Rev Immunol. 2013;31:259–83. Article CAS PubMed PubMed Central Google ...
IKATP is inhibited by intracellular ATP and activated by Mg-ADP, so that the channel activity is regulated by the ATP/ADP ratio, coupling cell metabolism to the Em. In responding to cytoplasmic nucleotide levels, KATP channel activity provides a unique link between cellular energetics and electric...
TRIBULUS TERRESTRIS HERBA EXTRACTUM SICCUM250mg is a dietary supplement that is used in complex therapies for men suffering from reduced libido, impotence, male infertility, lipid metabolism disorder or in women with climacteric and postcastration syndrome...
Innate immune response in COVID-19: single-cell multi-omics profile of NK lymphocytes in a clinical case series Silvia Barbon, Fabrizio Armellin, Verena Passerini, Sergio De Angeli, Simona Primerano, Laura Del Pup, Elisabetta Durante, Veronica Macchi, Raffaele De Caro, Pier Paolo...