It will review our current understanding of how metabolism of NK cells is differentially impacted in a variety of important situations. This is a rapidly expanding and exciting area of research that holds great potential for improving NK cell-based immunotherapies. 2019 Society for Leukocyte Biology....
Notably, Rfx7-deficient NK lymphocytes were rescued by interleukin 15 through engagement of the Janus kinase (Jak) pathway, thus revealing the importance of this signaling for maintenance of such spontaneously activated NK cells. Rfx7 therefore emerges as a novel transcriptional regulator of NK cell...
于是La Manno等人于2018年在Nature杂志上发表《RNA velocity of single cells》,提出了RNA速率分析方法,即基因表达状态的时间导数。在常见的单细胞RNA测序方案中,可以通过新生(未剪接)和成熟(剪接)mRNA的相对丰度来估计基因剪接和降解的速率,区分未剪接和剪接的mRNA,进一步直接估计细胞基因表达的动态分化。刚转录出的mR...
2018年7月19日,Cell Metabolism在线发表了中国科学技术大学生命科学与医学部、中科院天然免疫与慢性疾病重点实验室和合肥微尺度物质科学国家研究中心魏海明教授和田志刚教授课题组合作研究的论文Dysfunction of Natural Killer Cells by FBP1-induced Inhibition of Glycolysis during Lung Cancer Progression,该项研究成果展示了...
近期研究发现IL-12白细胞介素12(Interleukin 12, IL-12)能够刺激肥胖期间WAT中Ⅰ型先天淋巴细胞(Innate lymphoid cells, ILC)产生IFN-γ,进而驱动WAT炎症和全身代谢功能障碍。然而,在肥胖期间IL-12产生的具体机制以及WAT中产生IL-12的具体细胞种类尚不清楚。为了解决这一问题,加州大学洛杉矶分校的Timothy E. O’Sul...
of the unfolded protein response. Correspondingly, adoptive transfer of adipose tissueNK1.1NEGiNKT cells selectively restored metabolic function in obese mice. Further, we found an unexpected role forNK1.1POSiNKT cells in lean adipose tissue, as IFNγ licenses natural killer cell-mediated macrophage ...
The NK cell’s capacity to recognise and rapidly kill tumour cells without damaging healthy tissue suggests its potential for allogenic cancer immunotherapy. Indeed, there has been several efforts in developing clinical grade methods in generating large numbers of NK cells from multiple sources, for ...
Notably, Rfx7-deficient NK lymphocytes were rescued by interleukin 15 through engagement of the Janus kinase (Jak) pathway, thus revealing the importance of this signaling for maintenance of such spontaneously activated NK cells. Rfx7 therefore emerges as a novel transcriptional regulator of NK cell...
W. Metabolic landscape of the tumor microenvironment at single cell resolution. Nat. Commun. 10, 3763 (2019). Article PubMed PubMed Central Google Scholar Sonveaux, P. et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest. 118, 3930–...
of the unfolded protein response. Correspondingly, adoptive transfer of adipose tissueNK1.1NEGiNKT cells selectively restored metabolic function in obese mice. Further, we found an unexpected role forNK1.1POSiNKT cells in lean adipose tissue, as IFNγ licenses natural killer cell-mediated macrophage ...