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2A, B). WB revealed that at 1 week and 4 weeks after fat transplantation, the protein levels of PPARα, PGC-1α and CPT-1α, which are closely related to lipid metabolism, in the adipose tissue of the transplantation area were significantly greater in the ASC-assisted fat transplantation ...
Nature Metabolism volume 1, pages 1127–1140 (2019)Cite this article 2002 Accesses 32 Altmetric Metrics details Abstract Although mammalian target of rapamycin 1 (mTORC1) negatively regulates autophagy in cultured cells, how autophagy impacts mTORC1 signalling, in particular in an in vivo setting, ...
www.nature.com/scientificreports OPEN Lipid metabolism is associated with developmental epigenetic programming received: 23 February 2016 accepted: 19 September 2016 Published: 07 October 2016 Elizabeth H. Marchlewicz1, Dana C. Dolinoy1,2,3, Lu Tang4, Samantha Milewski5, Tamara R...
We identify an endogenous role for PPARα in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. We also suggest PPARα as a putative therapeutic target for age-related macular degeneration, which may be due in...
In many organisms, LB proteins (LBPs) have been found to be involved in lipid metabolism or in maintaining LB structure [19,20]. The former includes TAG lipases, which are required to remove the fatty acids from the backbone of the storage lipid. Mono- and Diacylglycerol (MAG and DAG) ...
NASH patients. Pathway analysis revealed that the metabolites are implicated in the down-regulation of necroptosis, amino acid metabolism, and regulation of lipid metabolism by PPAR-α, biogenic amine synthesis, fatty acid metabolism, and the mTOR signaling pathway. Cholesterol metabolism, DNA repair,...
Versions Notes Abstract Mendelian randomization (MR) analysis was performed to explore the effect of psoriasis on lipid metabolism traits and myocardial infarction (MI) risk and to analyze the proportion of the mediatory effect of lipid metabolism traits. Publicly accessible summary-level data for psor...
1、8.Lipid metabolism,Key notes,Structures and roles of fatty acids Fatty acid breakdown Fatty acid synthesis Triacylglycerols,8.1 Structures and roles of fatty acids,Fatty acids have a long hydrocarbon chain with a terminal carboxylic acid group.Most fatty acids have an even number of carbon ...
Bladder cancer (BLCA) is a common cancer associated with an unfavorable prognosis. Increasing numbers of studies have demonstrated that lipid metabolism affects the progression and treatment of tumors. Therefore, this study aimed to explore the function