The microbiota-derived sterol, Csta, was suggestively associated with a SNP on Chr 3. The SNP was located within an intron of theCALN1gene. To our knowledge, it is the first time this locus has been associated with lipid absorption or lipid metabolism and the result needs to be confirmed ...
Silymarin has been used for improving hepatic damage and lipid disorders, but its action mechanism remains to be clarified. Here, we investigate the contributions of the gut microbiota to the improvement of liver lipid metabolism by silymarin. We find i) strong and significant microbial shifts upon...
Autophagy restricts Mycobacterium tuberculosis during acute infection in mice Article 10 April 2023 Mycobacterium avium subsp. paratuberculosis exploits miRNA expression to modulate lipid metabolism and macrophage polarisation pathways during infection Article Open access 11 June 2022 Data...
which further regulates hepatic BAs metabolism, whereas TUDCA inhibits aging-triggered high-level of hepatic ATF4. Overall, Mel reducesC. jejuni-mediated deconjugation of TUDCA to inhibit aging-triggered high-level expression of hepatic FXR, which further decreases hepatic TMAO production, to relieve he...
L. incisais an oleaginous microalga that holds great promise for the study of lipid metabolism. In this study, an extensive LB proteome dataset was generated and successfully filtered for true LBPs.N. tabacumpollen tubes were used as an efficient tool for the verification of LB localization in...
Silymarin has been used for improving hepatic damage and lipid disorders, but its action mechanism remains to be clarified. Here, we investigate the contributions of the gut microbiota to the improvement of liver lipid metabolism by silymarin. We find i)
lipid metabolism. We replicated this analysis in a mouse model and two additional human cohorts and found equivalent modules in each. We performed causal inference and key driver analysis on the GLD module to identify master regulator genes includingLSS. Finally, we inhibited Lss in a mouse model...
Parameters related to obesity, glucose tolerance, lipid metabolism, hepatic steatosis and inflammation were examined. Small intestinal tissue and caecal content were collected for bacterial analysis. Results Mice in the Lp + GT group had significantly more Lactobacillus and higher diversity of ...
L. incisa is an oleaginous microalga that holds great promise for the study of lipid metabolism. In this study, an extensive LB proteome dataset was generated and successfully filtered for true LBPs. N. tabacum pollen tubes were used as an efficient tool for the verification of LB localization...
Since PA is pivotal for parasite lipid metabolism, the enzymes involved in PA metabolism are critical for understanding parasite pathogenesis. One such critical enzyme class is PAP, as it allows to fine-tune the balance between PA and DAG. Apicomplexa parasites possess three putative PAPs, none of...