51. Nicole R. Fortenbery, Kim H. T. Paraiso et al. “SHIP Influences Signals from CD48 and MHC Class I Ligands That Regulate NK Cell Homeostasis, Effector Function, and Repertoire Formation.” Journal of Immunology (2010). 5065 - 5...
2024年4月8日,来自美国加州大学洛杉矶分校的Timothy E. O’Sullivan在Nature Immunology期刊发表题为MEF2C regulates NK cell effector functions through control of lipid metabolism(MEF2C 通过控制脂质代谢调节NK细胞的效应功能)的文章。研究发现M...
2024年4月8日,来自美国加州大学洛杉矶分校的Timothy E. O’Sullivan在Nature Immunology期刊发表题为MEF2C regulates NK cell effector functions through control of lipid metabolism(MEF2C 通过控制脂质代谢调节NK细胞的效应功能)的文章。研究发现MEF2C缺乏导致NK细胞数量和功能下降,增加病毒感染风险。从机制上讲,MEF2C...
In this review, we provide a general overview of human NK cells, as opposed to murine NK cells, discussing their ontogeny, maturation, receptor diversity, types of responses, and effector functions. Furthermore, we also describe recent advances in human NK cell biology, including ...
自然杀伤细胞(natural killer cell,NK细胞) 是一种效应淋巴细胞,在机体抵抗肿瘤过程中发挥至关重要的作用。NK细胞无需预先致敏,即能够直接杀伤肿瘤细胞,并且能够通过分泌细胞因子促进适应性免疫的抗肿瘤作用【1】。基于上述原理,NK细胞在肿瘤免疫治疗中的价值已得到广泛认可【2】。然而,越来越多的研究表明,肿瘤生长过程...
[2] Beelen NA, Ehlers FAI, Kooreman LFS, Bos GMJ, Wieten L (2022) An in vitro model to monitor natural killer cell effector functions against breast cancer cells derived from human tumor tissue. Methods in Cell Biology doi.org/10.1016/bs.mcb.2022.05.001 ...
[2] Beelen NA, Ehlers FAI, Kooreman LFS, Bos GMJ, Wieten L (2022) An in vitro model to monitor natural killer cell effector functions against breast cancer cells derived from human tumor tissue. Methods in Cell Biology doi.org/10.1016/bs.mcb. 未完待续 knock knock美天旎,可免费获得相关...
可以看到上面的NK细胞细分,都是基于单个数据集,有很强烈的片面性,那么张泽民课题组的泛癌层面数据挖掘文章,2023年9月发表在CELL的《A pan-cancer single-cell panorama of human natural killer cells》,就很好的解决了这个问题。在NK单细胞亚群里面主要是CD56和CD16,其实对应的基因名字是NCAM1和FCGR3A ,它们在单...
[2] Beelen NA, Ehlers FAI, Kooreman LFS, Bos GMJ, Wieten L (2022) An in vitro model to monitor natural killer cell effector functions against breast cancer cells derived from human tumor tissue. Methods in Cell Biology doi.org/10.1016/bs.mcb.2022.05.001 ...
5.Perera Molligoda Arachchige AS. Human NK cells: From development to effector functions. Innate Immun. 2021 Apr;27(3):212-229. doi: 10.1177/17534259211001512. Epub 2021 Mar 24. PMID: 33761782; PMCID: PMC8054151.