Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat. Immunol. 20, 1656–1667 (2019). Article CAS PubMed Google Scholar Ghesquière, B., Wong, B. W., Kuchnio, A. & Carmeliet, P. Metabolism of stromal and immune cells in health and disease. Nature 511, 167–176...
Major progress has been made clinically in inhibiting the programmed death receptor 1 (PD-1)/PD-L1 interaction to enhance T cell-mediated immune function, yet the effectiveness of anti-PD-L1/PD-1 agents in enhancing natural killer (NK) cell’s function remains largely unknown. Susceptibilities ...
IL-12 partial agonists preferentially support T cell function with reduced activity on NK cells based on differences in IL-12Rβ1 expression IL-12 has shown promise as a cancer therapy by potentiating both T cells and NK cells; however, systemic administration of IL-12 leads to toxicity associa...
As cytokine therapy enhanced Env-specific NK cell activity, we sought to determine the impact on viral persistence amid ongoing ART. Independent of ART-mediated viral suppression, cytokine therapy failed to reduce the content of total cell-associated SIV-RNA (Fig.2a–c) or -DNA (Fig.2d–f) ...
(a) Cartoon of the experimental setup, and 6 conditions used to assess NK cell mechanical activity. (b,c) NK cells spread on flat MICA and nanowire-MICA surfaces, respectively, (d) Quantification of NK cell spreading on the tested surfaces (** p < 0.001, *** p < 0.0001) (e) ...
【FOG】Kill Cell, Interlinked. 05:54 【FOG】Fire in the hole (P, is for Plenty.) 02:22 【FOG】Ukraine Vol69 02:05 【FOG】Slava Ukraini 03:11 【FOG】frwd news - On the Front Lines of the War in Donet 03:04 【FOG】CQB for Charity 4K 01:30 【FOG】G b r s 03:34...
Package: 2pcs/box, then in a cartoon Delivery Time: 15-20 Days After Order Confirmed Port: Shenzhen Application: Illuminate Devices, Miner Lamp, Search Light, etc. Electric Toys, RC Models, Model Aircraft, Backup Power, Mobile Power Supply, Hand Electric Tools, etc.Packing...
The children stripped off their clothes and jumped into the river. 孩子们脱掉衣服跳进河里。 2. 夺去,剥夺;掠夺[(+of)] It was wrong of him to strip his daughter of the right to education. 他不该剥夺他女儿受教育的权利。 3. 拆卸,分解(机器;零件等)[(+down)] ...
In this paper, we review recent advances in materials and devices for artificial signaling, which have been applied to regulate NK cells, and systematically study the role of these signals in NK cell function. Keywords: NK cells; immune signaling; biomaterials; nanodevices; artificial immune ...
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