参考资料: [1].Niklas K. Björkström et al. Emerging insights into natural killer cells in human peripheral tissues. Nature Reviews Immunology (2016). [2 Maskalenko et al., Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders. Nature Reviews Drug Discovery,...
细胞表面抑制性和激活受体之间的动态平衡保证了NK细胞效应功能的调节。这些抑制性受体,如人类中的K1Rs(killer—cell immunoglobulin receptors)和小鼠中的Ly49的抑制性亚型以及同时存在于两个物种中的CD94/NKG2A异二聚体,可识别各种形式的主要组织相容性复合体I类(MHC-I)分子。因此,靶细胞上MHC-I分子的减少或缺失可...
Natural killer (NK) cells belong to the innate immune system. They are a heterogeneous population of lymphocytes found in the spleen and circulating in the blood, but there are also noncirculating tissue-resident NK cells in certain organs. NK cells were first discovered because they can kill ...
Lanier LL, Phillips JH, Hackett J Jr et al.(1986) Natural killer cells: Definition of a cell type rather than a function.J Immunol 137:2735–2739. Rautela J, Huntington ND (2017) IL-15 signaling in NK cell cancer immunotherapy...
1. Exploring the NK cell platform for cancer immunotherapy. Nat RevClin Oncol. 2020 Sep 15. 2. K Cell-Based Immune Checkpoint Inhibition. Front. Immunol., 13February 2020 3. CAR-expressing NK cells for cancer therapy: a ne...
2022年3月,发表在《Cells》(IF:7.666)上的一篇题为“Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions”的综述,揭示了改善NK细胞衰老在治疗与衰老相关疾病和延缓生物衰老过程中的重要作用。 NK细胞是机体重要的免疫细胞 ...
Natural Killer Cells The Power of Scroll to content about us We are dedicated to realizing the potential of natural killer (NK) cells for the treatment of cancer. Our proprietary technology is designed to harness the power of these important pathogen-fighting immune cells and is uniquely capable...
[5]Z. Davis,et al, Low-density PD-1 expression on resting human natural killer cells is functional and upregulated after transplantation. Blood Adv. 5, 1069–1080 (2021). [6]Joly E, Hudrisier D. What is trogocytosis and what is its purpose?[J]. Nature immunology, 2003, 4(9): 815...
70年代初NIC的研究人员在研究T细胞对靶细胞的特异杀伤时发现,正常对照小鼠的脾细胞可以像免疫小鼠的脾细胞一样杀伤某些肿瘤细胞,继而发现正常人体外周血淋巴细胞也可以天然杀伤某些癌细胞。这些细胞的杀伤功能不需要预先免疫或致敏,故取名为天然杀伤细胞(NK cells)。
深圳市达科为生物工程有限公司地址:深圳市南山区桃源街道光前工业区20栋4C邮编:518055Tel:0755-86235301Fax:0755-86235303Web:.dakeweE-mail:rd@dakewe自然杀伤(NK)细胞扩增培养试剂盒说明书NaturalKillerCellsCultureKitDKW35-CYT-NK001/002产品描述自然杀伤(NK)细胞扩增培养试剂盒(NaturalKillerCellsCultureKit)是一款...