参考资料: [1].Niklas K. Björkström et al. Emerging insights into natural killer cells in human peripheral tissues. Nature Reviews Immunology (2016). [2 Maskalenko et al., Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders. Nature Reviews Drug Discovery,...
自然杀伤细胞(natural killer cell, NK细胞)来源于骨髓淋巴样干细胞,其分化、发育依赖于骨髓及胸腺微环境,主要分布于骨髓、外周血、肝、脾、肺和淋巴结。NK细胞不同于T、B细胞,是一类无需预先致敏就能非特异性杀伤肿瘤细胞和病毒感染细胞的淋巴细胞[1]。 二、NK细胞激活及杀伤机制: 1.穿孔素/颗粒酶途径:NK细胞...
5.减缓癌性疼痛,改善睡眠,提高患者生命质量,延长患者的生命周期; 6.亚健康人群,采用NK细胞治疗可以降低患癌风险。 脐带血NK细胞的妙用 Cord Blood NK Cells 相对血液和骨髓,NK细胞及其祖细胞在脐带血中最为丰富。在上述研究中,研究人员发现一个单位的脐带血...
在肿瘤发生阶段,NK细胞和T淋巴细胞是肿瘤组织中主要的免疫细胞,随着肿瘤进展,Treg(Regulatory T cell,调节性T细胞)、MDSC(Myeloid-derived suppressor cells,骨髓来源的异质性细胞)、TAM(tumor-associated macrophages,肿瘤相关巨噬细胞)的数量逐渐增多,介导了免疫抑制性的微...
Natural Killer Cells The Power of Scroll to content about us We are dedicated to realizing the potential of natural killer (NK) cells for the treatment of autoimmune diseases. Our proprietary technology is designed to harness the power of these important pathogen-fighting immune cells and is ...
在咱们人体复杂神秘的免疫防御体系中,有一支常被忽视却至关重要的 “隐形战队” —— 自然杀伤细胞(Natural Killer Cells,简称 NK 细胞)。以往它低调无闻,可近年来,随着生物科技以令人瞠目结舌的速度飞速发展,NK 细胞的诸多神奇功效开始浮出水面,被大众所熟知。一系列严谨且前沿的科学研究,更是不断披露定期补充 ...
NK细胞（Natural Killer Cells），中文名为“自然杀伤细胞”，是人体先天免疫系统的核心战力。与需要抗原提示、活化过程的T细胞不同，NK细胞“天生就能杀”，不需要事先识别，看到异常就直接上。它们对病毒感染细胞、转化为肿瘤的细胞、异常表达表面受体的衰老细胞，都具备快速识别和清除能力。可惜的是，随着年龄增长，...
Natural killer (NK) cells are important cytotoxic lymphocytes of the innate immune system and are the first line of defense against infection and malignancy. They have innate ability to rapidly find and destroy virally infected and/or cancerous cells, while protecting healthy cells....
面对这类异常干细胞，传统药物无能为力。但自然免疫系统中的“清道夫”——自然杀伤细胞（Natural Killer Cells，NK细胞）具备识别并清除衰老细胞的天然能力。多项基础研究已证实，NK细胞可识别表达MICA/B、ULBP等“应激分子”的衰老细胞，通过释放穿孔素与颗粒酶B精准诱导其凋亡。特别是在脂肪组织中补充NK细胞，能够...
Natural killer (NK) cells belong to the innate immune system. They are a heterogeneous population of lymphocytes found in the spleen and circulating in the blood, but there are also noncirculating tissue-resident NK cells in certain organs. NK cells were first discovered because they can kill ...