Lanier LL, Phillips JH, Hackett J Jr et al.(1986) Natural killer cells: Definition of a cell type rather than a function.J Immunol 137:2735–2739. Rautela J, Huntington ND (2017) IL-15 signaling in NK cell cancer immunotherapy...
Natural killer (NK) cells belong to the innate immune system. They are a heterogeneous population of lymphocytes found in the spleen and circulating in the blood, but there are also noncirculating tissue-resident NK cells in certain organs. NK cells were first discovered because they can kill ...
[1]https://www.genengnews.com/artificial-intelligence/chatgpt-waxes-poetic-on-nk-cells/ [2] Natural killer cells for antiviral therapy《SCIENCE TRANSLATIONAL MEDICINE》4 Jan 2023，Vol 15, Issue 677，DAVEY M. SMITH [3] T cell receptor next-generation sequencing reveals cancer-associated repert...
自然杀伤细胞(Natural killer cell,NK细胞 ),是除 T细胞、B细胞之外的第三大类淋巴细胞,不仅与抗肿瘤、抗病毒感染和免疫调节有关,甚至参与超敏反应和自身免疫性疾病的发生。 图1 NK细胞与其他免疫细胞 NK细胞来源于骨髓造血干细胞,属于先天免疫系统的核心细胞,约占血液中所有免疫细胞数量的15%;主要分布于外周血、...
今年3月19日,生命科学领域顶级期刊《Cell》杂志发表了一篇关于NK细胞的Snapshot,用一张图总结了NK细胞的发育、分布、功能以及相关治疗方法。 图片来源:Cell 1. NK细胞的发育 在小鼠中,共同淋巴样祖细胞(common lymphoid progenitor,CLP)产生共同ILC前体(common ILC precursor,CILCP)。而CILCP可产生NK细胞、辅助样ILCs...
There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells express...
Natural killer (NK) cells are important cytotoxic lymphocytes of the innate immune system and are the first line of defense against infection and malignancy. They have innate ability to rapidly find and destroy virally infected and/or cancerous cells, while protecting healthy cells....
Natural killer (NK) cells are important cytotoxic lymphocytes of the innate immune system and are the first line of defense against infection and malignancy. They have innate ability to rapidly find and destroy virally infected and/or cancerous cells, while protecting healthy cells....
这种新型的三功能NKCE分子,包括靶向CD16、NKp46和肿瘤相关抗原CD19、CD20或EGFR的单克隆抗体片段。重定向优化细胞杀伤(ROCK)分子包括由两个diabodies(scFv二聚体)组成的四价双特异性接合器分子。ROCK分子AFM13靶向淋巴瘤相关抗原CD30和CD16a,...
图源文献:Natural killer cells for antiviral therapy 4 Jan 2023,Vol 15, Issue 677,DAVEY M. SMITH 尽管NK细胞产品症逐渐走入我们的视线中,但它仍然存在一些限制。 首先,输液后,NK细胞的增殖不像T细胞那么剧烈,对于受病毒感染的细胞清除效果也自然没有那么强,只有注入更多的NK细胞才可提升治疗效果。